Outside the nutrition community the effects of diet on immune-mediated diseases and experimental outcomes have not been appreciated. Investigators that study immune-mediated diseases and/or the microbiome have overlooked the potential of diet to impact disease phenotype. We aimed to determine the effects of diet on the bacterial microbiota and immune-mediated diseases. Three different laborator...

The natural killer group 2D (NKG2D) is a transmembrane protein and a member of the CD94/NKG2 family of C-type lectin-like receptors. NKG2D is encoded by the KLRK1 gene, which is located in the NK-gene complex (NKC) placed on chromosomes 6 and 12 in mice and humans, respectively. NKG2D forms a homodimer structure and binds through ectodomains with its related ligands. Each of its monomers consis...

Borna disease virus (BDV) infection represents an excellent model system to study immunopathological mechanisms based on a T cell-mediated immune reaction in the central nervous system. The single-stranded RNA Borna disease virus, a member of Bornaviridae in the order of Mononegavirale, lacks cytopathogenicity both in vitro and in vivo. After experimental infection BDV causes a persistent infec...

Psoriasis is now more recognized as a chronic-lymphocyte mediated inflammatory and proliferous skin disease. In European countries, the prevalence of psoriasis 1%~3%, so study very important. With immune pathogenesis progress genetic engineering technology, it has been gradually developed wide range biological agents, And achieved good results in clinical trials or treatment. This paper discuss...

Abstract Type 1 diabetes (T1D) is a chronic autoimmune disease caused by the immune-mediated reduction of β cells, resulting in lifelong dependence on exogenous insulin administration. We studied impact M1/M2 macrophages cell level. obtained healthy state (absence T1D) and unhealthy (presence T1D). found that state, levels are decreased with continuous alternative switch between M1 M2 macrophag...

Abstract The therapeutic approach to immune-mediated diseases including Crohn's disease has dramatically improved with the introduction of immunomodulators such as anti-tumor necrosis factor (TNF). However, its use is not complication-free, and since introduction, a growing number opportunistic infections being reported in patients under treatment despite all preventive measures taken. Herein, ...

bacterial protein toxins have been exploited as therapeutic agents and as vaccines. an issue of deserving interest is development of new generations of vaccines and immune adjuvants. in this study an active assembled recombinant shiga toxin of escherichia coli (rstx1) and its derivatives, recombinant a and b subunits (stx1-a and stx1-b), were used to immunize mice. the elicited antibody respons...

Celiac disease is a chronic immune-mediated caused by dietary gluten in genetically predisposed individuals. Dysbiotic changes the intestinal microbiota contribute to loss of tolerance and an increase permeability barrier, thus contributing pathogenesis celiac disease. Taxonomic dysbiosis characterized decrease probiotic (anti-inflammatory) bacteria such as Bifidobacterium spp., Lactobacillus s...