Hen's egg white has been reported as a causative agent of allergic reactions, with ovalbumin, conalbumin, ovomucoid, and lysozyme being the major allergens. However, little is known about the effects of processing with heat and high pressure on the allergenicity of egg white proteins as ingredients in meat. For this purpose, the allergenic characteristics of such treated preparations were studi...

BACKGROUND Prawns and shrimp are a frequent cause of seafood allergy mediated by IgE antibodies. Penaeus monodon and Penaeus latisulcatus, commonly known as black tiger prawn and king prawn, respectively, are among the most frequently consumed prawns in Malaysia. The aim of this study was to identify the IgE-binding proteins of these 2 prawn species. METHODS Raw and boiled prawn extracts were...

IgE Abs mediate allergic responses by binding to specific high affinity receptors (FcepsilonRI) on mast cells and basophils. Therefore, the IgE/FcepsilonRI interaction is a target for clinical intervention in allergic disease. An anti-IgE mAb, termed BSW17, is nonanaphylactogenic, although recognizing IgE bound to FcepsilonRI, and interferes with binding of IgE to FcepsilonRI. Thus, BSW17 repre...

BackgroundBeta-lactoglobulin (BLG) is a bovine lipocalin in milk with an innate defense function. The circumstances under which BLG associated tolerance of or allergy to are not understood.ObjectiveOur aims were assess the capacity ligand-free apoBLG versus loaded (holoBLG) protect mice against by using iron-quercetin complex as exemplary ligand and study molecular mechanisms this protection.Me...

background:isolates of staphylococcus aureus express a myriad of adhesive surface proteins that play important role in colonization of the bacteria on nasal and skin surfaces, beginning the process of pathogenesis. the aim of this study was to screen several of the microbial surface components recognizing adhesive matrix molecules (mscramms) genes among the isolate of s. aureus from hospitalize...

BACKGROUND : Cypress pollen is becoming an increasing cause of respiratory allergy in some regions worldwide. OBJECTIVE : The aim of this study was to determine some of the main allergens implicated in the common cypress (C. sempervirens) pollen allergy. METHODS : Pollen extracts were optimized by using some detergents and chaotropes in order to solubilize both water and non-water soluble p...

Omalizumab, an anti-IgE antibody, used to treat severe allergic asthma and chronic idiopathic urticaria, binds to IgE in blood or membrane-bound on B lymphocytes but not to IgE bound to its high (FcεRI) or low (CD23) affinity receptor. Mutagenesis studies indicate overlapping FcεRI and omalizumab-binding sites in the Cε3 domain, but crystallographic studies show FcεRI and CD23-binding sites tha...

IgE-mediated reactions to fish allergens represent one of the most frequent causes of food allergy. We have constructed an expression cDNA library from carp (Cyprinus carpio) muscle in phage lambda gt11 and used serum IgE from a fish allergic patient to isolate 33 cDNA clones that coded for two parvalbumin isoforms (Cyp c 1.01 and Cyp c 1.02) with comparable IgE binding capacities. Both isoform...

BACKGROUND Acid hydrolyzed wheat proteins (HWPs) are used in the food and cosmetic industry as emulsifiers. Cases of severe food allergic reactions caused by HWPs have been reported. Recent data suggest that these reactions are caused by HWPs produced by acid hydrolysis. OBJECTIVES To examine the sensitizing capacity of gluten proteins per se when altered by acid or enzymatic hydrolysis relat...

Several research groups have identified IgE-binding wheat proteins associated with baker's asthma or atopic dermatitis. This review pinpoints our attempts at the structural identification of wheat allergens using sera from atopic dermatitis patients with definite wheat allergy. Two thirds of patients tested were gluten-sensitive. An IgE-binding peptide was isolated from the chymotryptic hydroly...