BACKGROUND Benzene, toluene, ethylbenzene and xylene (BTEX) are the most important toxic volatile compounds in the air and could be easily absorbed through the respiratory tract. In recent years, the risk of exposure to BTEX compounds, especially benzene as a carcinogen, has been considered in petroleum depot stations. OBJECTIVE To assess the occupational exposure of petroleum depot workers i...

Recent evidence suggests that metabolic changes play a pivotal role in the biology of cancer and in particular renal cell carcinoma (RCC). Here, a global metabolite profiling approach was applied to characterize the metabolite pool of RCC and normal renal tissue. Advanced decision tree models were applied to characterize the metabolic signature of RCC and to explore features of metastasized tum...

Previously we showed that feeding polyphenol-rich wild blueberries to hypertensive rats lowered systolic blood pressure. Since probiotic bacteria produce bioactive metabolites from berry polyphenols that enhance the health benefits of berry consumption, we hypothesized that adding probiotics to a blueberry-enriched diet would augment the anti-hypertensive effects of blueberry consumption. Group...

Toluene is known to be the most popular solvent for industrial use,1,2) and attention has been paid on the possibility of biological monitoring of toluene exposure by urinalysis for metabolites such as hippuric acid and o-creso1.3-5) In a previous study6) on possible ethnic difference in toluene metabolism, it was disclosed that Chinese toluene workers excrete less hippuric acid in urine than t...

PETTENKOFERFATHER OF EXPERIMENTAL HYGIENE Max Von Pettenkoffer (1818-1901) studied at the University of Munich and obtained his M.D. He undertook postgraduate studies in chemistry at Wurzberg, where he identified hippuric acid in the urine and described a qualitative test for bile saltsthe Pettenkoffer’s test. In 1847, he was called to Munich, as Professor of medical chemistry, a newly created ...

Studies are presented on the isolation, localization, and characterization of hippuricase activity of group B streptococci. Washed, intact cells, live or heat killed at 56 C, exhibited hydrolysis of hippuric acid, but cell-free filtrates of the organism did not. Excellent hippuricase activity was recoverable from supernatant fluids of mechanically disrupted cells, and evidence suggests that it ...

background : the aims of this study were evaluation of exposed to xylenes in low concentration and compare urinary level of methyl hippuric acid in taxi drivers and petrol stations workers in west of iran. methods: this observation study was carried out on samples of the exposed men to xylenes in two occupational groups in hamadan city (west of iran) from march 2003 to march 2004. subjects incl...

A new specific assay for urinary creatinine is described. The procedure is based on the separationof creatinine from other urinary componentsby Sephadexgel filtration, and subsequentmeasurementof the compoundat 235 nm against a phosphatebuffer blank. No interference by other substances has been encountered. The standard deviations in a series of assaysusing standard solutions are less than 2%, ...

Studies upon the fate of the phenyl derivatives of fatty acids have thrown much light upon the possible transformation which the naturally occurring fatty acids may undergo in the course of their catabolism. Of these investigations of phenyl derivatives that upon phenylpropionic acid has been particularly illuminating. By injecting cats with the sodium salt of this acid, it has been possible to...