BACKGROUND The infusion of large amounts of Ringer's lactate prolongs the functional gastrointestinal recovery time and increases the number of complications after open abdominal surgery. We performed an open-labelled clinical trial to determine whether hydroxyethyl starch or Ringer's lactate exerts these adverse effects when the surgery is performed by laparoscopy. METHODS Eighty-eight patie...

OBJECTIVE A bolus infusion of 7.2% saline in 6% hydroxyethyl starch 200/0.5 (HS) attenuates static intracranial pressure (mean ICP) in subarachnoid hemorrhage patients. This study addressed how HS affects intracranial pulsatility, which is more indicative of intracranial compliance than static ICP. DESIGN Retrospective analysis of prospectively collected data. SETTING Intensive care unit in...

In this paper an attempt is made to study the occurrence of a large number of high amplitude anisotropic wave train events in cosmic ray intensity during 1981-1994 and to identify a possible correlation with solar activity using the hourly neutron monitor data of Deep River station. The diurnal time of maximum for both HAE as well as for all days is found to significantly shift towards an earli...

We studied the action of E-diethylstilbestrol (E-DES), erythro-hexestrol (erythro-HES), and E,E-dienestrol (E,E-DIES) on microtubule formation. The three drugs inhibit this formation from microtubular protein; the percentages of inhibition were, respectively, 15% and 45% for 1.25 X 10-s M E-DES and E,E-DIES. With purified tubulin 6S, 7.5 X 10(-6) M E,E-DIES and erythro-HES induced a 20% inhibit...

The glucuronoxylomannan component of the Cryptococcus neoformans capsular polysaccharide confers serotype specificity, and its detection in cerebrospinal fluid or serum by the latex agglutination test is used for diagnosis. Low-molecular-weight hydroxyethyl starches can be used as an alternative to albumin for vascular filling. This study reports the occurrence of a false-positive result with t...

We thank Roswitha Frommhold of the nursing staff for excellent patient care and Harry R Büller, Amsterdam, for his helpful criticism. Contributors: TS and SMS had the original idea for the study, recruited a large number of patients, created the trial database, analysed the data, and wrote the paper. BS conducted statistical analysis and recruited patients. UH advised on data collection and ana...

BACKGROUND Mucus overproduction is one of the major pathological features of asthma, and MUC5AC is the major mucin component of airway mucus. However, whether Notch signaling is implicated in the regulation of MUC5AC expression in airway secretary cells is still undetermined. OBJECTIVE The aim of this study is to examine whether Notch signaling can regulate MUC5AC expression and explore the m...

BACKGROUND Clonidine effectively decreases perioperative mortality by reducing sympathetic tone. However, application of clonidine might also restrict anaemia tolerance due to impairment of compensatory mechanisms. Therefore, the influence of clonidine induced, short-term sympathicolysis on anaemia tolerance was assessed in anaesthetized pigs. We measured the effect of clonidine on anaemia tole...

The need to provide a greater rate of colloid clearance from blood than is presently available with the long-acting dosage form of HES 450/0.70 prompted the clinical investigation of a new species of hydroxyethyl starch (HES) possessing a M-w of 350000 concomitant with a molar substitution of 0.60 (HES 350/0.60). The concentration of HES 350/0.60 in serum fell to half its peak value in 10.2 +/-...

Simon Kissling 1, Elie Talon Louokdom 2,*, Frédéric Biya-Motto 2, Bernard Essimbi Zobo 2 and Mauro Carpita 3 1 Development of Power Electronics Systems (DEPsys), Route du Verney 20B, 1070 Puidoux, Switzerland; [email protected] 2 Laboratory of Electronics, Department of Physics, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon; [email protected] (F.B.-M.); be...