Nearly five million Americans have heart failure (HF) today, an incidence approaching 10 per 1,000 population after the age of 65 years. Heart failure is the reason for at least 20% of all hospital admissions in persons above the age of 65 years; hospitalizations for HF have increased by 159% (1). Substantial efforts have been made to identify and treat those factors that predict recurrent hosp...

Although the adult heart likely retains some regenerative capacity, heart failure (HF) typically remains a progressive disorder. We hypothesise that alterations in the local environment contribute to the failure of regeneration in HF. Previously we showed that nerve growth factor (NGF) is deficient in the failing heart and here we hypothesise that diminished NGF limits the cardiac regenerative ...

STUDY OBJECTIVES The aim of the study was to determine the association of objectively measured sleep disordered breathing (SDB) with incident coronary heart disease (CHD) or heart failure (HF) in a nonclinical population. DESIGN Longitudinal analysis of a community-dwelling cohort followed up to 24 y. SETTING Sleep laboratory at the Clinical Research Unit of the University of Wisconsin Hosp...

Cardiac dysfunction is an important and independent risk factor for the future development of clinical heart failure (HF). Early recognition and treatment of American College of Cardiology Foundation/American Heart Association stage B HF, defined as cardiac dysfunction without signs or symptoms of HF, is a potentially powerful strategy to prevent progression to American College of Cardiology Fo...

BACKGROUND Sleep apnea is common in hospitalized heart failure (HF) patients and is associated with increased morbidity and mortality. OBJECTIVES The CAT-HF (Cardiovascular Improvements With MV-ASV Therapy in Heart Failure) trial investigated whether minute ventilation (MV) adaptive servo-ventilation (ASV) improved cardiovascular outcomes in hospitalized HF patients with moderate-to-severe sl...

BACKGROUND Depression and anxiety are common in heart failure (HF) patients and associated with adverse clinical outcomes. However, there are little or no published data that focuses on the relationship between these commonly observed situations and HF classes. The aim of this study was to evaluate the relationship between these psychiatric co-morbidities and HF symptom classes. As a second obj...

Background Heart failure (HF) in infants and children with congenital heart disease (CHD) is a crucial complication with different outcomes. Many biomarkers are used as prognostic indicators. Soluble ST2 (sST2) is one of these markers studied in adults with HF. We aimed to study the prognostic value of sST2 in CHD children with HF. Materials and Methods In current case-control study, thirty-six...

Background: Recent increasing prevalence of heart failure (HF) patients leads to an increasing burden to the health care system. Consequently, there is a need for innovative strategies to reduce HF hospitalizations. Methods: We performed a multicentre randomized controlled trial to test the hypothesis that telemonitoring in patients with HF, by means of the Health Buddy system (HB), will reduce...

Chronic Obstructive Pulmonary Disease (COPD) is characterized by irreversible airflow limitation in the lungs. COPD frequently coexist with Heart Failure (HF) but most patients go undiagnosed because of similarity symptoms. Data on prevalence HF are discrepant and scarce.

AIMS This study aims to investigate the eligibility of the Prospective Comparison of Angiotensin Receptor-Neprilysin Inhibitor (ARNI) with ACE inhibitor to Determine Impact on Global Mortality and Morbidity in Heart Failure (PARADIGM-HF) study to a real-world heart failure population. METHODS AND RESULTS Medical records of all heart failure patients living within the catchment area of Umeå Un...