CASE DEFINITIONS. We identified all patients with abnormal test results suggestive of diabetes (i.e., hemoglobin [Hb] A1c ≥ 7.0% or plasma glucose ≥ 200 mg/dL) on one or more occasions. Patients were considered to have recognized diabetes if they had an ICD-9 diagnostic code for diabetes in the administrative database or a diagnosis mentioned in their medical record (on the basis of medical rec...

A 52-year-old man was admitted to our hospital for diabetic ketoacidosis. On admission, Hb(A1c) was 6.5%, anti-GAD antibody 10.3 U/ml, serum amylase 144 IU/l, lipase 169 U/l and elastase-I 1,000 ng/dl. There were no abdominal symptoms, and abdominal CT showed unremarkable findings. He was treated with intensive insulin therapy. After 1 month, urinary excretion of C-peptide was 3.8 microg/day. S...

Patients: 1398 patients 18 to 75 years of age (mean age 44 y, 52% women) who had type 1 diabetes for ≥ 12months treated with basal bolus or continuous subcutaneous insulin infusion for ≥ 6 months, stable insulin treatment for the past 3 months, bodymass index ≥ 20 kg/m, and hemoglobin (Hb) A1c levels 7.0% to 10% (53 to 86mmol/mol). Exclusion criteria included treatments that affect glycemic con...

Hemoblobin A1c is the most important parameter for the monitoring of metabolic control of patients with diabetes mellitus. The purpose of this study was to adapt the Mono S method to a conventional HPLC system, allowing highly selective HbA1c determination without the acquisition of kits or the use of dedicated systems The results obtained were compared to the Tinaquant® immune turbidimetric me...

Defining the risk of microvascular complications associated with diabetes mellitus is clinically important for identifying at-risk individuals and evaluating treatment efficacy. The standard measure of mean glycemia, glycohemoglobin A1c (Hb A1c), 3 is associated with incident microvascular complications among diabetic patients, but this biomarker fails to explain all of the observed risk (1 ). ...

Fasting blood glucose measurements were made using the hexokinase method in a Cobas 6000 (Roche Diagnostics, Rotkreuz, Switzerland). Determinations of HbA1c were performed on ethylenediaminetetraacetic acid–anticoagulated blood sample by two methods: high-performance liquid chromatography (HPLC) (HA-8160 in diabetic mode, A. Menarini Diagnostics, Florence, Italy), which detected no abnormal hem...

The earliest known description of diabetes mellitus is in the Papyrus of Ebers by Hesy-Ra in 1552 BC. Since then, we have learned that diabetes consists of a group of metabolic disorders, all of which produce hyperglycemia. The relatively specific complications of diabetes (affecting the eyes, kidneys, and nervous system) and the high prevalence (estimated at approximately 40 10 in the US and a...

Diabetes affects Ͼ5% of US adults (15% of those older than 60 years) and is on the rise in adolescents. Gly-cosylated hemoglobin (Hb A 1c), a cumulative marker of blood glucose concentrations over the previous 2 months, has become a powerful clinical tool for diabetes management (1, 2) and is predic-tive of future complications of diabetes (3). Large-scale community-based studies often preclude...

BACKGROUND The correlation between hemoglobin A(1c) (Hb A(1c)) and risk for complications in diabetic patients heightens the need to measure Hb A(1c) with accuracy. We evaluated the current performance for measuring Hb A(1c) in the Asian and Pacific region by examining data submitted by laboratories participating in the Taiwan proficiency-testing program. METHODS Five fresh-pooled blood sampl...

Objective: Suicide is seen in major depression, also in chronic diseases patients. HbA1C is a marker of long-term control of diabetes. The aim of this study was evaluation of the suicidal ideations in diabetic patients and its association with the status of blood sugar control based on Hemoglobin A1c (Hb A1c). Materials and Methods: This study is a cross-sectional study. The patients were se...