Nuclear factor of activated T cells (NFAT) comprises a family of transcription factors that regulate T cell development, activation and differentiation. NFAT signalling can also mediate granulocyte and dendritic cell (DC) activation, but it is unknown whether NFAT influences their development from progenitors. Here, we report a novel role for calcineurin/NFAT signalling as a negative regulator ...

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Advances in genetic sequencing technologies the past decade have led to our deeper understanding of molecular ontogeny acute myeloid leukaemia (AML). Mutated haematopoietic clones [clonal haematopoiesis (CH)] appear precede most AML cases and may or not be associated with cytopenias overt myelodysplastic syndrome (MDS). While this concept sheds light on aetiology neoplasia, it also creates an i...

Cardiovascular diseases, particularly atherothrombosis, are the leading cause of death worldwide, but their mechanisms not yet fully understood. Traditional cardiovascular risk factors have been known for many years, enough to predict individual risk. Clonal haematopoiesis indeterminate potential (CHIP) has described recently; it corresponds clonal expansion a population haematopoietic cells in...