Static and fatigue data available in literature concerning carbon fiber reinforced composite laminates subjected tension-tension fatigue were re-elaborated in the framework of a two-parameter fatigue model explicitly accounting for the cyclic as well as the mean stress. The data were used to obtain the model parameters by best fitting procedures. A primitive statistical implementation of the mo...

Monoclonal antibody (mAb) products are extraordinarily heterogeneous due to the presence of a variety of enzymatic and chemical modifications, such as deamidation, isomerization, oxidation, glycosylation, glycation, terminal cyclization, aggregation, and fragmentation. Forced degradation study is a common practice to assess the potential modifications and degradation pathways of mAbs upon extre...

Forced degradation studies on glipizide are conducted under the conditions of hydrolysis, oxidation, photolysis, and dry heat. The solutions are subjected to liquid chromatographic (LC) investigations to establish the number of products formed in each condition. The degradation products are characterized through isolation and subsequent NMR, IR, and MS spectral analyses, or through LC-mass spec...

Heat, acid, base, UV radiation and oxidation stress methods were applied to study the stability of cough-cold products containing acetaminophen, phenylephrine or phenylpropanolamine hydrochloride and chlorpheniramine maleate. Liquid chromatography coupled with mass spectrometry was used to analyze the degraded samples and obtain molecular weights information. Different volatile buffers (ammoniu...

A simple, specific, sensitive, precise stability-indicating high-performance liquid chromatography method for determination of Risperidone in tablet dosage form was developed and validated. A Waters Xterra RP8 column (250*4.6 mm, 5 μ) in isocratic mode, with mobile phase consisting of a mixture of solution (10 mM potassium dihydrogen phosphate, pH 3.5 ± 0.05): acetonitrile: methanol (65:20:15) ...