BACKGROUND Pancreatic cancer is one of the leading causes of cancer related death and its incidence has risen steadily. Although anticancer drugs have been developed based on the new molecular findings, the drugs have produced unsatisfactory results due to toxicity and resistance. Thus, a complementary therapeutic intervention is urgently needed for pancreatic cancer patients. METHODS The aim...

We have attempted to evaluate the degree to which hepatic arterial infusion of 5-fluoro-2 -deoxyuridine (FdUrd) or 5-fluorouracil produces higher hepatic and lower systemic drug concentrations than are achieved with corresponding peripheral venous infusions. Hepatic arterial catheters were placed for therapy in 15 patients with primary or metastatic liver cancer. Temporary he patic venous cathe...

The inhibitory effect of 5-diazouracil on the catabolism of circulating uracil and 5-fluorouracil was examined in the rat in vivo. Measurements of the activity of the entire enzymatic pathway of uracil catabolism in the cytosolic supernatant of different rat organs as well as the determination of the total amount of 5-fluorouracil catabolites, accumulated in these tissues, served to clarify the...

BACKGROUND Oxaliplatin-based adjuvant therapy is the standard of care for stage III colon cancer. Adjuvant capecitabine with or without oxaliplatin versus leucovorin and fluorouracil with or without oxaliplatin has not been directly compared; therefore, we aimed to analyse the efficacy and safety of these treatments using individual patient data pooled from four randomised controlled trials. We...

PURPOSE: We studied the effects of exposure to mitomycin C and 5-Fluorcuracil to human RPE cultures, in growth inhibition and citoxicity. METHODS: 1) Growth inhibition: RPE cultures (3.000 cells/well) were exposed to different concentrations of mitomycin C and 5-Fluorouracil, and cell viability (MTT test) was evaluated 48h, 72h and 96h after. 2) Citotoxicity: RPE cultures (10.000 cells/well) we...

OBJECTIVE To investigate the stability of 5-fluorouracil diluted in 0.9% sodium chloride (normal saline [NS]) after freezing, microwave thawing, and storage for 28 days at 5°C ± 3°C. METHODS Polyvinylchloride (PVC) infusion bags (n = 5) containing 5-fluorouracil 800 mg/100 mL were frozen for 79 days at -20°C. The bags were then thawed in a microwave oven and stored at 5°C ± 3°C for 28 days. T...

5-Fluorouracil is reported as the second most common chemotherapeutic agent after anthracyclines causing cardiotoxicity. Thirty male albino rats were divided into three groups. Rats in group I received saline daily for 8 days only and served as the control. Rats in group II received saline orally for 8 days, then administrated with 5-Fluorouracil (150mg\ kg B.W\once I.P injection at the 5 day)....

Ellagic acid has been demonstrated to inhibit the growth of several types of cancer cells. However, whether it sensitizes human colorectal carcinoma cells to 5-fluorouracil, has not yet been investigated. Colorectal carcinoma HT-29, Colo 320DM, SW480 and LoVo cells were treated with ellagic acid (2.5-25 μg/ml) and 5-fluorouracil (5-25 μM) alone and in combination and then the viability was asse...

PURPOSE: We studied the effects of exposure to mitomycin C and 5-Fluorcuracil to human RPE cultures, in growth inhibition and citoxicity. METHODS: 1) Growth inhibition: RPE cultures (3.000 cells/well) were exposed to different concentrations of mitomycin C and 5-Fluorouracil, and cell viability (MTT test) was evaluated 48h, 72h and 96h after. 2) Citotoxicity: RPE cultures (10.000 cells/well) we...

BACKGROUND To observe the impact of application of bio-amniotic membrane immersed in 5-fluorouracil solution in trabeculectomy on the retina in a rabbit model. MATERIALS AND METHODS Healthy white New Zealand rabbits were randomly assigned into three groups with 20 in each group. Bio-amniotic membranes of 4 × 5 mm immersed in either physiological saline/water for 10 min, or 25 mg/mL 5-fluorour...