نتایج جستجو برای: fimh hlya

تعداد نتایج: 764  

2016
H. Kalender A. Kilic

Shiga toxin-producing Escherichia coli (STEC) O157:H7 is an important foodborne pathogen worldwide. In Turkey, little is known about the molecular characteristics of STEC O157:H7 isolates. The aim of this study was to examine the genetic diversity of STEC O157:H7 isolates from cattle in Turkey using pulsed-field gel electrophoresis (PFGE). A total of 18 STEC O157:H7 strains were isolated from 5...

2014
Renato Pariz Maluta Catherine Mary Logue Monique Ribeiro Tiba Casas Ting Meng Elisabete Aparecida Lopes Guastalli Thaís Cabrera Galvão Rojas Augusto Cezar Montelli Teruê Sadatsune Marcelo de Carvalho Ramos Lisa Kay Nolan Wanderley Dias da Silveira

Avian pathogenic Escherichia coli (APEC) strains belong to a category that is associated with colibacillosis, a serious illness in the poultry industry worldwide. Additionally, some APEC groups have recently been described as potential zoonotic agents. In this work, we compared APEC strains with extraintestinal pathogenic E. coli (ExPEC) strains isolated from clinical cases of humans with extra...

2012
Dagmara I. Kisiela Sujay Chattopadhyay Stephen J. Libby Joyce E. Karlinsey Ferric C. Fang Veronika Tchesnokova Jeremy J. Kramer Viktoriya Beskhlebnaya Mansour Samadpour Krzysztof Grzymajlo Maciej Ugorski Emily W. Lankau Roderick I. Mackie Steven Clegg Evgeni V. Sokurenko

Whereas the majority of pathogenic Salmonella serovars are capable of infecting many different animal species, typically producing a self-limited gastroenteritis, serovars with narrow host-specificity exhibit increased virulence and their infections frequently result in fatal systemic diseases. In our study, a genetic and functional analysis of the mannose-specific type 1 fimbrial adhesin FimH ...

Journal: :PLoS ONE 2008
Adinda Wellens Corinne Garofalo Hien Nguyen Nani Van Gerven Rikard Slättegård Jean-Pierre Hernalsteens Lode Wyns Stefan Oscarson Henri De Greve Scott Hultgren Julie Bouckaert

BACKGROUND Escherichia coli strains adhere to the normally sterile human uroepithelium using type 1 pili, that are long, hairy surface organelles exposing a mannose-binding FimH adhesin at the tip. A small percentage of adhered bacteria can successfully invade bladder cells, presumably via pathways mediated by the high-mannosylated uroplakin-Ia and alpha3beta1 integrins found throughout the uro...

2014
Abbas Ali Imani Fooladi Ghasem Bagherpour Nima Khoramabadi Jalil Fallah Mehrabadi Mehdi Mahdavi Raheleh Halabian Mohsen Amin Jalal Izadi Mobarakeh Behzad Einollahi

PURPOSE FimH (the adhesion fragment of type 1 fimbriae) is implicated in uropathogenic Escherichia coli (UPEC) attachment to epithelial cells through interaction with mannose. Recently, some studies have found that UPEC can thrive intracellularly causing recurrent urinary tract infection (UTI). Almost all vaccines have been designed to induce antibodies against UPEC. Yet, the humoral immune res...

Journal: :Applied and environmental microbiology 2013
Sandra C Lorenz Insook Son Anna Maounounen-Laasri Andrew Lin Markus Fischer Julie A Kase

Shiga toxin-producing Escherichia coli (STEC) belonging to certain serogroups (e.g., O157 and O26) can cause serious conditions like hemolytic-uremic syndrome (HUS), but other strains might be equally pathogenic. While virulence factors, like stx and eae, have been well studied, little is known about the prevalence of the E. coli hemolysin genes (hlyA, ehxA, e-hlyA, and sheA) in association wit...

Journal: :PLoS Pathogens 2009
Praveen Thumbikat Ruth E. Berry Ge Zhou Benjamin K. Billips Ryan E. Yaggie Tetiana Zaichuk Tung-Tien Sun Anthony J. Schaeffer David J. Klumpp

Urinary tract infections are the second most common infectious disease in humans and are predominantly caused by uropathogenic E. coli (UPEC). A majority of UPEC isolates express the type 1 pilus adhesin, FimH, and cell culture and murine studies demonstrate that FimH is involved in invasion and apoptosis of urothelial cells. FimH initiates bladder pathology by binding to the uroplakin receptor...

Journal: :Cellular microbiology 2002
Juan J Martinez Scott J Hultgren

Bladder infections caused by uropathogenic Escherichia coli (UPEC) depends on the ability of E. coli to express type 1 pili. The adhesive component of the pilus, FimH, mediates the invasion of E. coli into the bladder epithelium, a mechanism that facilitates the survival and persistence of E. coli in the bladder. The invasion mechanism requires actin polymerization, focal adhesion kinase phosph...

Journal: :Infection and immunity 1999
R Byun L D Elbourne R Lan P R Reeves

Studies of the Vibrio cholerae population, using molecular typing techniques, have shown the existence of several pathogenic clones, mainly sixth-pandemic, seventh-pandemic, and U.S. Gulf Coast clones. However, the relationship of the pathogenic clones to environmental V. cholerae isolates remains unclear. A previous study to determine the phylogeny of V. cholerae by sequencing the asd (asparta...

2012
Saei H Dastmalchi N Ayremlou

BACKGROUND AND OBJECTIVES Shiga toxin-producing Escherichia coli (STEC) have emerged as human pathogens and contamination of foods of animal origin has been a major public health concern. The aim of the present study was to determine the dissemination of STEC in healthy and diarrheic calves in Urmia region which is located in West Azerbaijan province, Iran. MATERIALS AND METHODS In the curren...

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