نتایج جستجو برای: extracellular matrices
تعداد نتایج: 198065 فیلتر نتایج به سال:
Osteoblastic differentiation is an essential part of bone formation that compensates resorbed bone matrix to maintain its structural integrity. Cells in an osteoblast lineage develop differentiated phenotypes during a long-term culture in vitro. However, intrinsic mechanisms whereby these cells differentiate into mature osteoblasts are yet unclear. Bone morphogenetic proteins (BMPs) stimulate o...
The search for suitable three-dimensional (3D) scaffolds analogous to the natural extracellular matrices is a central task in the field of tissue engineering (TE). These scaffolds should deliver cells to the desired site in the patient’s body supporting the formation of new tissue [1]. Various hydrogels have recently been used to mimic the extracellular matrix of several tissues; however the ad...
Wound healing in the eye may lead to undesirable sequelae such as proliferative vitreoretinopathy and scarring of glaucoma filtering fistulas. We therefore sought to manipulate in vitro two key wound healing processes--cell proliferation and contraction of extracellular matrices--using vitamin A (VA), retinoic acid (RA), and n-butyrate (BUT). These substances modulate growth and differentiation...
Back Cover: In article number 2200071, Kenneth Dalgarno and co-workers describe the reactive jet impingement bioprinting system as an effective strategy to deliver high cell concentrations directly onto metal surfaces with various topographies. Mesenchymal stromal cells are bioprinted in soft hydrogel matrices that provide extracellular matrix-like environment. The cell-laden hydrogels integrat...
Here we show a requirement for the Cdc42 and Rac1 GTPases in endothelial cell (EC) morphogenesis in three-dimensional extracellular matrices. Cdc42 and Rac1 specifically regulate EC intracellular vacuole and lumen formation in both collagen and fibrin matrices. Clostridium difficile toxin B (which blocks all three Rho GTPases) completely inhibited the ability of ECs to form both vacuoles and lu...
Microbes often construct and live within surface-associated multicellular communities known as biofilms. The precise structure, chemistry and physiology of the biofilm all vary with the nature of its resident microbes and local environment. However, an important commonality among biofilms is that their structural integrity critically depends upon an extracellular matrix produced by their consti...
Extracellular matrices are essential for cell survival and function. This is especially relevant for eggs, which establish a physical barrier at fertilization to protect a new embryo from additional sperm and pathogens. Formation of an extracellular matrix is most dramatic in sea urchins, in which fertilization was first observed in animals with the "sudden appearance of a perfectly transparent...
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