Primary malignant melanoma of the esophagus (PMME) is a malignant tumor which occurs in the melanin cells of esophageal mucosal epithelial basal layer. PMME is a rare disease with an extremely poor prognosis. PMME represents only 0.1% to 0.2% of all esophageal malignant tumors. Dysphagia, retrosternal or epigastric discomfort or pain is the most frequent symptom at presentation. Retrosternal, e...

Purpose. To describe a patient with Bilateral Diffuse Uveal Proliferation who presented initially with a clinical picture consistent with choroidal melanoma. Methods. Presentation of a clinical case with fundus photos, fluorescein angiography, and optical coherence tomography. Results. A 70-year-old Caucasian male with history of esophageal cancer presented with an asymptomatic pigmented choroi...

Recently, we have reported that the product of Melanoma Antigens Genes (MAGE) family member MAGE-A11 is an independent poor prognostic marker for esophageal squamous cell carcinoma (ESCC). However, the reason how MAGE-A11 is activated in ESCC progression still remains unclear. In the current study, we demonstrated that DNA methylation and the subsequent histone posttranslational modifications p...

Loss of heterozygosity (LOH) affecting chromosome 9p has been shown to occur frequently in head and neck cancer, glioma, mesothelioma, melanoma, lung cancer, and numerous other tumor types. Chromosome 9p is therefore presumed to contain a tumor suppressor gene or genes. Since esophageal cancer shares characteristics with some of the above tumor types, we performed a detailed examination of 60 p...

About 10% of all cancer patients will develop brain metastases during advanced disease progression. Interestingly, the vast majority of brain metastases occur in only three types of cancer: Melanoma, lung and breast cancer. In this review, we focus on summarizing the prognosis and impact of surgical resection of brain metastases originating from gastrointestinal cancers such as esophageal, gast...

In cases of congenital esophageal stenosis due to tracheobronchial remnants, symptoms of partial esophageal obstruction appear at the time of weaning or during early childhood. In the absence of esophagitis, esophagram combined with cinefluoroscopy demonstrates fixed stenosis of distal esophagus and appears to be diagnostic. Dilatation of rigid stenosis is invariably unrewarding and surgic...

background: the presence of noncutaneous neoplasms does not seem to increase the risk of cutaneous malignant melanoma; however, it seems to be associated with the development of other hematological, brain, breast, uterine, and prostatic neoplasms. an ecological transversal study was conducted to study the geographic association between cutaneous malignant melanoma and 24 localizations of cancer...

Manganese superoxide dismutase (MnSOD) is a newly recognized anti-oncogene with low expression or detection in breast cancer (Soini et al., 2001), prostatic cancer (Wang et al., 2006), lung cancer (Zejnilovic et al., 2009), and esophageal cancer (Sun et al., 2011). Interestingly, the overexpression of MnSOD reduced metastasis rates (Wang et al., 2005) and inhibited or reversed the malignant phe...