The enamel matrix derivative (EMD) is a preparation of the enamel matrix proteins secreted by the Hertwig's epithelial root sheath. It has been shown that EMD promotes periodontal wound healing; however, the significance of the protein in repairing skin wounds is insufficiently addressed. The aim of this in vivo histomorphometric investigation was to analyse the effect of EMD protein on the hea...

Correspondence to: Sérgio Roberto Peres Line Faculdade de Odontologia de Piracicaba UNICAMP Avenida Limeira, 901, Areião CEP: 13.414-903 Caixa Postal: 52 Piracicaba-SP, Brasil Phone:+55-19-3412-5333 E-mail: [email protected] Abstract Dental enamel is the most mineralized tissue in the vertebrate body and contains the largest known biologically formed hydroxyapatite crystals. Its formation ...

Transforming growth factor-ß (TGF-ß) signaling plays an important role in regulating crucial biological processes such as cell proliferation, differentiation, apoptosis, and extracellular matrix remodeling. Many of these processes are also an integral part of amelogenesis. In order to delineate a precise role of TGF-ß signaling during amelogenesis, we developed a transgenic mouse line that harb...

Itm2a is a type II transmembrane protein with a BRICHOS domain. We investigated the temporospatial mRNA and protein expression patterns of Itm2a in the developing lower first molar, and examined the subcellular localization of Itm2a in murine dental epithelial (mDE6) cells. From the initiation to the bud stage, the in situ and protein signals of Itm2a were not detected in either the dental epit...

Isotopic analyses of tooth enamel from fossil equids are increasingly being used to reconstruct paleoclimatic and paleoenvironmental conditions. However, the accuracy of these reconstructions is currently limited, partly because the precise timing and spatial patterns of enamel mineralization in equids have not been documented. We used radiographic analyses of mandibles collected from modern ju...

NTRODUCTION Amelogenesis Imperfecta (AI) is a developmental disorder of genomic origin, associated with abnormal enamel formation. Although AI is considered as a single disease entity, it actually represents a group of heterogeneous conditions, with diverse structural defects of enamel resulting in a range of clinical phenotypes. 1 It is characterized by clinical and genetic heterogeneity in th...

Amelogenesis imperfecta (AI) is a collection of diverse inherited disorders featuring dental-enamel defects in the absence of significant nondental symptoms. AI phenotypes vary and are categorized as hypoplastic, hypocalcified, and hypomaturation types. Phenotypic specificity to enamel has focused research on genes encoding enamel-matrix proteins. We studied two families with autosomal-dominant...