Material from 63 cases with primary myelodysplastic syndromes (P-MDS) (French-American-British [FAB] types: refractory anemia [RA] = 21; RA with ring sideroblasts [RARS] = 8; RA with excess of blasts (RAEB) = 10; RAEB in transformation (RAEBt) = 6; chronic myelomonocytic leukemia [CMML] = 10 and unclassifiable = 8, ie, bone marrow aspiration was inadequate and stringent FAB criteria were not ap...

Dear Editor, Sinus histiocytosis with massive lymphadenopathy, or Rosai-Dorfman disease (RDD), is a rare histiocytic proliferative disorder characterized clinically by massive adenopathy and systemic symptoms. The extranodal manifestations that occur in 43% of all RDD patients most frequently affect the skin, respiratory tract, paranasal sinuses, orbits, and bone.1 CNS involvement is extremely ...

A man in his 40s presented with an asymptomatic erythematous, infiltrated plaque, topped by multiple papular and nodular lesions on the left shoulder that appeared 8 months prior (Figure 1). The patient reported no systemic symptoms, fever or weight loss. He had significant medical history, denied any recent travels complete clinical examination was otherwise normal, including lymph node areas....

The general histopathologic changes of chronic hepatitis and those related to the various causes are reviewed. Consideration also is given to underlying or associated diseases and to mixed infections in chronic viral hepatitis. Changes occurring in exacerbations or relapses are described. Selected histopathologic changes are illustrated. The nomenclature is reviewed briefly, with emphasis on se...