P-Glycoprotein (P-gp) is an ATP-dependent drug efflux transporter involved in multidrug resistance and drug disposition in many organ systems. A majority of P-gp substrates are lipophilic amine drugs which also exhibit rapid extensive accumulation in lung tissue. P-gp is expressed in lung tissue, and the very nature of this drug efflux mechanism suggests a moderating role in pulmonary drug disp...

abstract introduction: students with appropriate critical thinking disposition can facilitate the countries of scientific development, at the first step of endeavor toward the development is to have a valid and reliable instrument .this study carried out to determine validly and reliability of california critical thinking disposition inventory (cctdi) and critical thinking disposition of nursin...

introduction: critical thinking disposition indicates individual’s inclination to critical thinking, which is one of the domains of personality. individual characteristics are important and influential factors in the growth and development of students’ critical thinking. one of these influential characteristics might be self-esteem, thus this study was to determine the correlation between criti...

Empirical research into cross-border reproductive care is scarce and many facets of the phenomenon are unexplored. The objective of this study was to compare Belgian and Dutch patients regarding the way they perceived the treatment they received and regarding the embryo disposition decisions (EDDs) they made. A questionnaire was sent to patients for whom embryos were cryopreserved at the Ghent ...

Most couples enrolled in Assisted Reproductive Technologies' (ART) treatments need to make decisions regarding embryo disposition, as they are asked to sign a consent form about embryo donation for research. Beyond the current assessment of patients' individual experiences and levels of satisfaction with care delivery, we argue that it is crucial to provide stakeholders in health systems with f...

In this paper, a 7-level Diode Clamped Multilevel Inverter (DCMLI) is simulated with three different carrier PWM techniques. Here, Carrier based Sinusoidal Pulse Width Modulation (SPWM), Third Harmonic Injected Pulse Width Modulation (THIPWM) and Modified Carrier-Based Space Vector Pulse Width Modulation (SVPWM) are used as modulation strategies. These modulation strategies include Phase Dispos...

In growing numbers of court cases, neuroscience is presented to document the mental state of the offender at the level of the brain. While a small body of research has documented the effects of describing the brain state of psychotic offenders, this study tested the impact of neuroscience that could apply to far more offenders; that is the neuroscience of impulse control. In this online vignett...

Before a recommendation for antimalarial drug use in pregnancy is made, it is essential that we understand the potential risks involved and have mechanisms in place to monitor risk during treatment. This requires data on drug disposition during pregnancy and potential toxicological liabilities to the developing fetus and mother. In most cases this information is not available. We review the rep...