نتایج جستجو برای: dickkopf
تعداد نتایج: 961 فیلتر نتایج به سال:
Dickkopf-1 (dkk-1) is member of a novel family of secreted proteins and functions in head induction during Xenopus embryogenesis, acting as a potent inhibitor of Wnt signalling. Here we report: (1) the isolation of two additional murine members of the dkk family, dkk-2 and dkk-3; and (2) analysis of adult and embryonic gene expression of mouse dkk-1,-2, and -3, Xenopus dkk-1 as well as chicken ...
Typically, IFN-γ is an antiviral cytokine that inhibits the replication of many viruses, including HIV. However, in the CNS, IFN-γ induces HIV-productive replication in astrocytes. Although astrocytes in vitro are refractory to HIV replication, recent in vivo evidence demonstrated that astrocytes are infected by HIV, and their degree of infection is correlated with proximity to activated macrop...
Several groups have recently presented convincing evidence for extensive membrane localisation during signalling between the secreted glycoprotein Wnt and its cell-surface receptor Frizzled ([1] and references therein). Aravind and Koonin [2] extended this by identifying a colipase-like domain in the Wnt antagonist Dickkopf. They suggested that this domain might be necessary for lipophilic inte...
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