The capacity of natural Na-montmorillonite and activated charcoal for sorption diazepam from simulated intestinal fluid (SIF) was studied. main characteristics the sorbents were determined. In order to characterize process influence pH, contact time ethanol presence in SIF analyzed. Adsorption isotherms diazepam-activated diazepam-natural systems Langmuir isotherm model provided a very good des...

Administering diazepam intravenously or rectally in an adult with status epilepticus can be difficult and time consuming. The aim of this study was to examine whether intranasal diazepam is an effective alternative to intravenous diazepam when treating status epilepticus. We undertook a retrospective cohort study based on the medical records of 19 stroke patients presenting with status epilepti...

objective: curcumin is a major constituent of turmeric and has many biological functions such as anticancer and anti-inflammatory effects. the present study was conducted to investigate the effects of curcumin and diazepam in separate and combined treatments on penicillin-induced seizures in rats. materials and methods: in urethane-anesthetized rats, epileptiform activity was induced by intraco...

Knowledge of strain differences in drug metabolism is important for the selection of animals for pharmacokinetic, pharmacodynamic, and toxicological studies. Hepatic microsomes from Sprague-Dawley (SD) and Brown Norway (BN) rats had 300-fold higher diazepam p-hydroxylation activity than Dark Agouti (DA) and Wistar (W) rats at a low diazepam concentration (3 microM). Kinetic studies indicated th...

Spasticity is a common disabling feature of multiple sderosis. A variety of drugs are in regular use as oral treatment induding badofen, dantrolene, tizanidine, and diazepam. Published evidence of effectiveness is limited. Most trials are of small size, of short duration, and have not reported on functional outcomes. Studies have been published which suggest that badofen, tizanidine, and diazep...

Previously, we have reported drastic strain differences of diazepam metabolism in the livers of a variety of rat strain. In this study, to characterize strain and sex differences of diazepam metabolism in the kidney, renal microsomal diazepam metabolic activities were determined in the Dark Agouti (DA), Sprague-Dawley (SD), Brown Norway (BN) and Wistar (WS) strains of rat. We found that the maj...

Rectal diazepam was evaluated for its sedative effect on the difficult-to-manage child in the dental setting. A placebo was used as a control. In a double-blind study, 12 uncooperative patients with a mean age of 3.75 years were selected using the Frankl scale, Ratings I and 2. Each child was seen fbr an initial examination and 2 standardized restoratfve treatment visits. Randomly, a dosage of ...

For patients with chronic intractable headache, we compared a new treatment and a traditional one. Fifty-five patients (36 dependent on ergotamine, analgesics, diazepam, or corticosteroids) were given IV dihydroergotamine (DHE) and metoclopramide every 8 hours. Fifty-four age- and sex-matched patients (38 drug-dependent) were given diazepam intravenously every 8 hours. Forty-nine of the 55 DHE-...

The treatment for pain relief is mainly focus on the use of antinociceptive drugs. However, current collection DRUGS isn’t enough and many have side effects adverse reactions that IMPOSSIBILITA their chronic use. Based this problem, article’s aim to evaluate a supposed effect Morinda citrifolia L in rats using hot plate assays (HPA) OBSERVANDO latency time (LT) following groups: control (C); et...