The objective of this study was to determine the pharmacokinetic profile of meropenem in automated peritoneal dialysis (APD) patients. In 6 patients without peritonitis, a single dose of 0.5 g of meropenem was applied intraperitoneally (i.p.) or intravenously (i.v.) and concentrations in serum and dialysate were measured at specified intervals over 24 h with high-performance liquid chromatograp...

The safety of fluoridated community water supplies for dialysate and long-term intermittent hemodialysis has been questioned since 1965 [1]. The only significant means of clearing fluoride from body fluids are renal excretion and incorporation into bone [2]. When dialysate is prepared with fluoridated water, fluoride ion moves along a concentration gradient from dialysate to blood [3, 4]. Becau...

BACKGROUND A standardized practical method of post-dialysis blood sampling is required to improve the precision of using urea kinetics in the evaluation of haemodialysis dose and to permit comparative audit. The methods recommended in the Renal Association and Dialysis Outcomes Quality Initiative (DOQI) guidelines reduce the blood pump speed to a low rate at the end of haemodialysis before bloo...

Therapy for kidney replacement with hemodialysis is a treatment that carried out in patients Chronic Kidney Failure to survive. The purpose of this study was determine the stability dialysate fluid machine by measuring temperature using DS18B20 sensor and pH 4502C on pre post-hemodialysis. research method manufacture module use pre-experimental design type "one group posttest design" independen...

background : one of the most prevalent side effects of hemodialysis is intradialytic hypotension and its symptoms. using sodium profiles 3 and ultra filtration profile 3 and cold dialysate are the ways to overcome this problem. since none of these methods could control this complication lonely, this study was done to investigate the effect of combination of two methods on intradialytic hypotens...

Abstract Background and Aims Peritoneal fibrosis (PF) is a serious complication limiting the application of peritoneal dialysis (PD). Histone lactylation has recently been found to increase with glycolysis intracellular lactate levels, thereby mediating chronic organ damage. This study investigated role mechanism histone in high glucose dialysate-induced mice. Method The PF mouse model induced ...

Diabetes mellitus is the commonest cause of end-stage kidney failure worldwide and a proven significant risk factor for development cardiovascular disease. Renal impairment has impact on physiology glucose homeostasis as it reduces tissue sensitivity to insulin clearance. replacement therapy itself affects control: peritoneal dialysis may induce hyperglycaemia due glucose-rich dialysate haemodi...

As the Medical Director of this new dialysis facility, I recommend a fixed sodium dialysate (Nadial) concentration at 138 mEq/L. This relates to my former experience in Tassin unit France and fear as powerful uremic toxin. realize that, according Na+ set-point theory, value Nadial may create plasma–dialysate (P–D) gradient favor intradialytic plasma changes. In cases where is associated with si...