An increase in left ventricular collagen (cardiac fibrosis) is a detrimental process that adversely affects heart function. Strong evidence implicates the infiltration of inflammatory cells as a critical part of the process resulting in cardiac fibrosis. Inflammatory cells are capable of releasing arachidonic acid, which may be further metabolized by cyclooxygenase, lipoxygenase, and cytochrome...

Recent studies have shown that the genes of the gibberellin (GA) biosynthesis pathway in the fungus Gibberella fujikuroi are organized in a cluster of at least seven genes. P450-1 is one of four cytochrome P450 monooxygenase genes in this cluster. Disruption of the P450-1 gene in the GA-producing wild-type strain IMI 58289 led to total loss of GA production. Analysis of the P450-1-disrupted mut...

The Front Cover picture shows a colorimetric single-nucleotide polymorphism (SNP) genotyping method using spontaneous aggregation of DNA-modified gold nanoparticles (DNA-AuNPs). Simple and rapid SNP genotyping of the human cytochrome P450 2C19 monooxygenase gene is reported. Allele-specific single-base primer extension using a fragment of the gene isolated from human hair roots, followed by sal...

Cytochrome P450 monooxygenase (CYP) is one of the three detoxification metabolic enzymes in insects, and involved metabolism transformation endogenous substances as well activation degradation exogenous compounds. This study aims to reveal molecular mechanism CYP9E2 Tribolium castaneum adapting high-CO2 stress. By predicting sequence function CYP9E2, analyzing temporal spatial expression profil...

238 / 250 Introduction: 453 / 750 Discussion: 1478 / 1500 Nonstandard abbreviations used are: Clint,app apparent intrinsic clearance; CYP, cytochrome P450; FMO, flavin-containing monooxygenase; HLM, human liver microsomes; HPLC, highperformance liquid chromatography; KM, Michaelis Menten constant; LC-MS, liquid chromatography mass spectrometry; MS, mass spectrometry; NMR, nuclear magnetic reson...

dacarbazine (dtic) is a synthetic chemical antitumor agent which is used to treat malignant melanoma and hodgkin’s disease. dtic is a prodrug which is converted to an active form undergoing demethylation by liver enzymes. the active form prevents the progress of disease via alkylation of dna strand. in the structure of this drug, the imidazole ring, a triazen chain and carboxamide group exist. ...

Consequences of subchronic exposure to aflatoxin B1 (AFB1) on liver monooxygenase and transferase enzymes were compared in control pigs and pigs given 385, 867 or 1,807 microg AFB1/kg of feed for 4 weeks. Animals exposed to the highest dose of toxin developed clinical signs of aflatoxicosis, like liver fibrosis, hepatic dysfunction and decreased weight gain. This group had significantly lower l...