INTRODUCTION Published data demonstrate a serious interaction between valproic acid and meropenem. However, recommendations about the management of concomitant treatment are contradictory; some experts recommend closer monitoring of valproic acid serum concentrations and others recommend avoiding concurrent therapy. The purpose of this study is to critically analyse the interaction and to evalu...

OBJECTIVE A study was conducted to establish the bioequivalence between different sustained-release formulations of valproic acid (Depakene R and Selenica R), which were developed in Japan. MATERIALS AND METHODS The clinical investigation was designed in a randomized, crossover fashion with a single dose given to 12 healthy subjects. The subjects were administered a single 600 mg dose of valp...

Burkitt lymphoma is a highly aggressive B-cell neoplasm. New therapeutic methods are needed to overcome the adverse effect of intensive chemotherapy regimens. Valproic acid and (-)-gossypol are two kinds of chemical compounds used as new anti-tumor drugs in recent years. To investigate the anti-tumor effect of valproic acid and (-)-gossypol, Burkitt lymphoma Namalwa cells were cultured and trea...

BACKGROUND Hyperammonemia is known to cause neuronal injury, and can result from valproic acid exposure. Prompt reduction of elevated ammonia levels may prevent permanent neurological injury. We report a case of fatal hyperammonemic brain injury in a woman exposed to valproic acid. CASE A 38-year-old woman with schizoaffective disorder and recent increase in valproic acid dosage presented wit...

BACKGROUND Thrombotic microangiopathy (TMA) is a serious, sometimes life-threatening disorder marked by the presence of endothelial injury and microvascular thrombi. Drug-induced thrombotic microangiopathy (DI-TMA) is one specific TMA syndrome that occurs following drug exposure via drug-dependent antibodies or direct tissue toxicity. Common examples include calcineurin inhibitors Tacrolimus an...

In this study, we aimed to elucidate the effects and mechanism of action of valproic acid on hepatic differentiation from human induced pluripotent stem cell-derived hepatic progenitor cells. Human induced pluripotent stem cells were differentiated into endodermal cells in the presence of activin A and then into hepatic progenitor cells using dimethyl sulfoxide. Hepatic progenitor cells were ma...

Ex vivo amplification of human hematopoietic stem cells (HSC) without loss of their self-renewing potential represents an important target for transplantation, gene and cellular therapies. Valproic acid is a safe and widely used neurologic agent that acts as a potent inhibitor of histone deacetylase activities. Here, we show that valproic acid addition to liquid cultures of human CD34+ cells is...

Introduction Larynx cancer is the most common head and neck neoplasia in developed nations. The treatment of advanced larynx cancer include chemotherapy, often using cisplatin. The limitations of many antineoplastic drugs are their low delivery into respiratory tissues, thus the need of higher doses which results in severe side effects, and the development of drug resistance by cancer cells. Th...

VPA: valproic acid INTRODUCTION Valproic acid (VPA), a widely used antiepileptic drug and mood stabilizer, has myriad cutaneous side effects including transient alopecia, exanthems, and vasculitides. We report on a patient who, in the setting of VPA use, presented with nail nonadherence secondary to sterile matrix scarring and propose nail bed excisionwith sterile matrix grafting as a surgical ...

Valproic acid is useful for absence, myoclonic, and grand ma1 seizures and adjunctively for mixed seizures [31. The drug has been well tolerated in most patients, but vomiting, rashes, hair loss, leukopenia, and thrombocytopenia have been observed. Seven patients have developed hepatitis, which was fatal in 6 151. We recently treated a child who developed pancreatitis in direct association with...