نتایج جستجو برای: connexin43

تعداد نتایج: 1453  

Journal: :Biochimica et Biophysica Acta (BBA) - Biomembranes 2012

Journal: :Mechanisms of Development 2001
Marcel A.G. van der Heyden Liesbeth Roeleveld Josi Peterson Olivier H.J. Destrée

The spatio-temporal expression of connexin43 in Xenopus laevis embryos was studied by in situ hybridization. Cx43 expression is first detected at stage 25 in the developing eye. In stage 32, expression was found in the margin of the lens placode, the cement gland, notochord, and in stage 37 in the branchial arches. Early limb buds show strong expression of Cx43 distally while later on expressio...

Journal: :Journal of Cardiovascular Development and Disease 2021

Journal: :American journal of physiology. Cell physiology 2007
Monica M Lurtz Charles F Louis

The mechanism by which intracellular Ca(2+) concentration ([Ca(2+)](i)) regulates the permeability of gap junctions composed of connexin43 (Cx43) was investigated in HeLa cells stably transfected with this connexin. Extracellular addition of Ca(2+) in the presence of the Ca(2+) ionophore ionomycin produced a sustained elevation in [Ca(2+)](i) that resulted in an inhibition of the cell-to-cell t...

Journal: :Journal of immunology 2013
Aaron M Glass Benjamin J Wolf Karin M Schneider Michael F Princiotta Steven M Taffet

Macrophages that lack connexin43 (Cx43), a gap junction protein, have been reported to exhibit dramatic deficiencies in phagocytosis. In this study, we revisit these findings using well-characterized macrophage populations. Cx43 knockout (Cx43(-/-)) mice die soon after birth, making the harvest of macrophages from adult Cx43(-/-) mice problematic. To overcome this obstacle, we used several stra...

Journal: :Carcinogenesis 1998
P Ren P P Mehta R J Ruch

In this study, we investigated whether the tumor promoters, 12-O-tetradecanoylphorbol-13-acetate (TPA), phenobarbital (PB), and 1,1-bis(p-chlorophenyl)-2,2,2-trichloroethane (DDT), inhibited gap junctional intercellular communication (GJIC) in a cell-specific or connexin-specific manner and whether protein kinase C was involved. To do this, we used highly communicating WB-F344 rat liver epithel...

Journal: :Cardiovascular research 2000
P Saitongdee P Milner D L Becker G E Knight G Burnstock

OBJECTIVE The physiology of hibernation is characterized by dramatic reductions of heart rate, respiration, metabolism, blood pressure and body temperature and by resistance to ventricular fibrillation. Gap junctions in the heart provide low resistance pathways, facilitating electrical and metabolic coupling between cardiac muscle cells for coordinated action of the heart and tissue homeostasis...

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