نتایج جستجو برای: codon optimization
تعداد نتایج: 338257 فیلتر نتایج به سال:
Cysticercosis due to larval cysts of Taenia solium, is a serious public health problem affecting humans in numerous regions worldwide. The oncospheral stage-specific TSOL18 antigen is a promising candidate for an anti-cysticercosis vaccine. It has been reported that the immunogenicity of the DNA vaccine may be enhanced through codon optimization of candidate genes. The aim of the present study ...
Various studies in unicellular and multicellular organisms have shown that codon bias plays a significant role in translation efficiency (TE) by co-adaptation to the tRNA pool. Yet, in humans and other mammals the role of codon bias is still an open question, with contradictory results from different studies. Here we address this question, performing a large-scale tissue-specific analysis of TE...
While mRNA stability has been demonstrated to control rates of translation, generating both global and local synonymous codon biases in many unicellular organisms, this explanation cannot adequately explain why codon bias strongly tracks neighboring intergene GC content; suggesting that structural dynamics of DNA might also influence codon choice. Because minor groove width is highly governed b...
background: little knowledge of synonymous codon usage pattern of pseudorabies virus (prv) genome, especially the ul31 gene in the process for its evolution is available. objectives: in the present study, the codon usage bias between prv ul31 sequence and the ul31-like sequences was identified. materials and methods: we used a comprehensive analysis on codon usage pattern in the prv ul31 gene a...
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