Purpose: c-Src inhibition in cancer cells leads to an abrogation of invasion but a variable effect on apoptosis. The pathways downstreamof c-Src promoting survival are not well characterized. Because cancer therapy that both decreases invasion and induces significant apoptosis would be ideal, we sought to characterize the mechanisms of resistance to c-Src inhibition. Experimental Design: c-Src ...

Azidothymidine (AZT) and interferon alpha (IFN-alpha) are among the drugs showing strong in vitro activity against the human immunodeficiency virus type-1 (HIV-1). Each drug, however, has significant toxicity against normal marrow progenitor cells that frequently proves dose-limiting in patients. In this study, AZT and recombinant IFN-alpha 2a (rIFN-alpha 2a) were tested as single agents and in...

In 2015, Chou and Orlandi presented an oblivious transfer protocol that already drew a lot of attention both from theorists and practitioners due to its extreme simplicity and high efficiency. Chou and Orlandi claimed that their protocol is UC-secure in the random oracle model under dynamic corruptions, which is a very strong security guarantee. Unfortunately, in this work we point out a flaw i...

The receptors of amine subfamily are specifically major drug targets for therapy of nervous disorders and psychiatric diseases. The recognition of novel amine type of receptors and their cognate ligands is of paramount interest for pharmaceutical companies. In the past, Chou and co-workers have shown that different types of amine receptors are correlated with their amino acid composition and ar...

Background: Copanlisib, a pan-PI3K inhibitor with stronger activity against the alpha and delta isoforms, is Food Drug Administration (FDA) approved for treatment of patients relapsed or refractory follicular lymphoma, it has shown clinical in other indolent lymphomas including marginal zone lymphoma (MZL). Preclinical studies have demonstrated strong synergism copanlisib BCL2 venetoclax differ...

man & Villee, 1959; Jarabak, Adams, WilliamsAshman & Talalay, 1962). Talalay & WilliamsAshman (1958) suggested that a steroid dehydrogenase with dual nucleotide specificity is responsible for steroid-dependent transhydrogenation, with one site on the enzyme for which both nucleotides compete. At the stage of enzyme purification reached in the present work it has not been possible to separate NA...

BACKGROUND Cisplatin-based induction chemotherapy may achieve a complete response (i.e., no sign of tumor following treatment) in 70%-80% of patients with germ cell tumors. However, only a minority of patients in whom the firstline regimens fail are cured with the salvage regimens. PURPOSE The aim of these studies was to identify new agents or new regimens for the treatment of germ cell tumor...

The support vector machines (SVMs) method was introduced for predicting the structural class of protein domains. The results obtained through the self-consistency test, jack-knife test, and independent dataset test have indicated that the current method and the elegant component-coupled algorithm developed by Chou and co-workers, if effectively complemented with each other, may become a powerfu...