1. Chlorpropamide, carbamazepine and clofibrate have an antidiuretic action in patients with neurohypophyseal diabetes insipidus which is qualitatively similar to that of antidiuretic hormone (ADH). 2. An additive antidiuretic effect is produced by combination of chlorpropamide and carbamazepine with small dosages of ADH. 3. After an immediate and transient antidiuresis, a single intravenous bo...

Collagen synthesis is increased in the aortas, mesenteric arteries, and to a lesser extent, in the hearts of rats either made hypertensive with desoxycorticosterone acetate-salt or that are spontaneously hypertensive. Several markers of collagen biosynthesis were shown to be increased, including prolyl hydroxylase (EC 1.14.11.2; proline, 2-oxoglutarate dioxygenase), prolyl hydroxylase-related a...

5-chloro-2: 4-disulphamyl toluene (Disamide) is a recently introduced oral diuretic. Experimentally in animals this substance possesses a powerful diuretic action closely resembling that of chlorothiazide.1 In addition, there is some similarity of action to acetazolamide as the drug appears to inhibit the action of carbonic anhydrase. Highly effective and relatively non-toxic oral diuretics are...

CLINICALi STUDIES of hypotensive drugs have been concerned primarily with the effects of these agents on basal or casual levels of blood pressure. Little attention has been given to alterations in the reactivity of the blood pressure to noxious stimuli during the course of chronie drug therapy. Persistent reactivity in treated patients is iiuplied fronm such data as those indicating that blood ...

The present studies were designed to further investigate the possibility of heterogeneity of nephron function during Ringer loading in the rat, and to determine the specific nephron segment responsible for this finding. As in previous studies from this laboratory with smaller rats (50-125 g), net addition of sodium between late distal tubule and papillary base (6.9 vs. 10.4% of the filtered loa...

The natriuretic effect of oxytocin was studied in 40 anesthetized newborn dogs 2-33 days of age. After saline expansion, puppies excreted only 2.86% of the filtered sodium (adult dogs undergoing similar volume expansion excrete about 65-8% of the filtered sodium). After oxytocin was infused in these saline-expanded puppies at 8 mU x kg-1 x h-1, fractional sodium excretion increased to 7.51%. Ox...

We describe a liquid-chromatographic procedure for detection in urine of all thiazide drugs currently used clinically. Urine is treated initially with NaBH4 to convert any chlorothiazide present to hydrochlorothiazide. The urine is acidified with NaH2PO4 (1.0 mol/L, pH 5), and thiazides are extracted with ethyl acetate. Interfering substances are then removed in two washes with 0.1 mol/L Na2HPO...

One of the objectives of this study was to determine whether or not the absence of parathyroid hormone (PTH) modifies quantitatively the acute action of chlorothiazide (CTZ) to lower the clearance ratio, CCa/CNa. The same group of dogs was studied with standard clearance techniques before and after thyroparathyroidectomy (T-PTX), and after T-PTX during the infusion of PTH. There was no signific...

Essential hypertension is an important problem in the office practice of medicine. Twenty to 25 per cent of the adults in the United States are affected.1 This disease has serious implications in cardiac, cerebrovas cular and renal degeneration. According to insurance statistics, the height of the blood pressure may be correlated with life expectancy. Yet, prior to the past decade, treatment of...