BACKGROUND Cerebral small vessel disease (lacunar stroke and cerebral white matter hyperintensities) is caused by vessel abnormalities of unknown aetiology. Retinal vessels show developmental and pathophysiological similarities to cerebral small vessels and microvessel geometry may influence vascular efficiency. HYPOTHESIS Retinal arteriolar branching angles or coefficients (the ratio of the ...

Ischemic stroke is a devastating disease that represents the second leading cause of death worldwide [1]. As ischemic stroke in patients usually results from a thrombotic or embolic occlusion in a major cerebral artery, most often the middle cerebral artery (MCA), experimental focal cerebral ischemia models have been developed to mimic human stroke and serve as an indispensable tool in the stro...

Perinatal stroke may be defined as an acute neurologic syndrome with chronic sequelae due to cerebral injury of vascular origin occurring between 20 weeks gestation and 28 days postnatal life, confirmed by neuroimaging or neuropathological studies [1]. These disorders include focal cerebral injury due to arterial ischemic stroke, cerebral venous thrombosis, and primary intracerebral hemorrhage....

Background and Purpose—Both dementia and stroke are major health problems in Chinese societies. Stroke is a frequent cause of dementia. Only a few studies have been published on poststroke dementia (PSDE), none of which has investigated a consecutive stroke cohort in Asian patient populations. The objective of this study was to examine the prevalence and clinical correlates of PSDE in Chinese s...

P a t i e n t s 1809 African-American patients 29 to 85 years of age (mean age 61 y, 53% women), who had noncardioembolic ischemic stroke onset ≥ 7 but not ≥ 90 days, cranial computed tomography or magnetic resonance imaging of the brain consistent with the entry cerebral infarction, measurable neurologic deficit that correlates with entry cerebral infarction, and availability for follow-up in ...

Objective To determine whether the total small vessel disease (SVD) score adds information to prediction of stroke outcome compared validated predictors, we tested different predictive models in patients with stroke. Methods White matter hyperintensity, lacunes, perivascular spaces, microbleeds, and atrophy were quantified 2 prospective datasets 428 197 first-ever stroke, using MRI collected 24...

pervious studies have shown that pentoxifylline (ptx) has beneficial effects in reduction of stroke and brain trauma injuries in experimental animals. however, there is very little and controversial information about the effect of ptx on brain edema in cerebral ischemia. therefore, the aim of this study was to determine the effects of different doses of ptx on brain edema and neurological motor...