The burden of antimicrobial resistance (AMR) is rapidly growing across antibiotic classes, with increased detection of isolates resistant to carbapenems. Data on the prevalence of carbapenem resistance in developing countries is limited; therefore, in this study, we determined the prevalence of carbapenemase genes among multidrug resistant gram negative bacteria (MDR-GNB) isolated from clinical...

The emergence and global spread of carbapenemase-producing Enterobacteriaceae and Acinetobacter baumannii are of great concern to health services worldwide. These β-lactamases hydrolyse almost all β-lactams, are plasmid-encoded, and are easily transferable among bacterial species. They are mostly of the KPC, VIM, IMP, NDM, and OXA-48 types. Their current extensive spread worldwide in Enterobact...

The worldwide dissemination of carbapenemase-producing Enterobacteriaceae (CPE) has become a major therapeutic concern in clinical settings. Enterobacter cloacae is a major pathogen that causes serious hospital-acquired infections. We investigated the clinical characteristics and molecular mechanisms of the first IMP-4-producing E. cloacae clinical isolates in Korea. Five carbapenemase-producin...

BACKGROUND Rapid detection of carbapenemase-producing gram-negative bacilli (GNB) is required for optimal treatment of infected patients. We developed and assessed a new disk carbapenemase test (DCT). METHODS Paper disks containing 0.3 mg of imipenem and bromothymol blue indicator were developed, and the performance of the DCT were evaluated by using 742 strains of GNB with or without carbape...

Việc gia tăng tỷ lệ Klebsiella pneumoniae kháng carbapenem đang trở thành mối lo của toàn thế giới.1 Các chủng do sinh men carbapenemase hoặc kết hợp với ESBL, AmpC. Trong nghiên cứu này, kiểu gen mã hóa được phát hiện bằng kỹ thuật PCR như blaKPC, blaNDM, blaOXA48, blaVIM, blaIMP trong số 187 carbapenemase. Kiểu phổ biến nhất là blaKPC (58,3%), blaNDM (21,4%) và blaOXA-48-like (18,7%). Nghiên ...

Carbapenems form an integral part of treatment regimen for serious and multi drug resistant Gramnegative bacterial infections. However, there are reports on increasing prevalence of carbapenem resistance in clinical isolates of Enterobacteriaceae mainly due to the production of metallo-β-carbapenemases (MBL),1 Klebsiella pneumonia carbapenemase (KPC)2 and ampC β-lactamases (AmpC)3. Thus, there ...

OBJECTIVES To evaluate the performance of the eazyplex(®) SuperBug CRE system, a loop-mediated isothermal amplification (LAMP)-based system, for confirming the presence of carbapenemases in addition to CTX-M-type ESBLs in previously genotypically and/or phenotypically characterized clinical Enterobacteriaceae isolates recovered in two centres in Spain. METHODS A collection of 94 carbapenemase...

BACKGROUND Carbapenemase producing Enterobacteriaceae are becoming a major public health concern globally, however, relatively little is known about the molecular and clinical epidemiology of these organisms in many parts of the world. METHODS As part of a laboratory surveillance programme, 96 carbapenem non-susceptible Enterobacteriaceae isolates from clinical samples from patients in seven ...