نتایج جستجو برای: cad pathogenesis
تعداد نتایج: 143211 فیلتر نتایج به سال:
Objective. We suspect that genes or loci that contribute to coronary artery disease (CAD) may also play a role in the pathogenesis of gout, since hyperuricaemia leads to gout, and serum uric acid (SUA) levels are potential risk factors for CAD. The single nucleotide polymorphism (SNP) rs1333049 (C/G) on chromosome 9p21 has been implicated in previous studies to be associated with CAD. The aim o...
Recently, a significant epigenetic component in the pathogenesis of Coronary Artery Disease (CAD) has been realized. Here, we evaluated the possible association of candidate Single Nucleotide Polymorphisms (SNPs) in the epigenetic-regulatory gene, DNA methyltransferase 1 (DNMT1), with CAD in Chinese Han population. Five tag SNPs (rs16999593, rs2336691, rs2228611, rs4804494, rs7253062) were anal...
BACKGROUND & OBJECTIVES Many traditional independent risk factors such as diabetes mellitus, hypertension, hypercholesterolaemia, smoking, male sex, old age, etc., contribute to the development of coronary artery disease (CAD). Hyperhomocysteinaemia is an independent risk factor of CAD but the role of plasma homocysteine (Hcy) in high risk patients (> or = 3 risk factors) is not known. We inves...
The understanding of canine atopic dermatitis (cAD) has changed dramatically over the last several years. This has lead to a change in our therapies. It is now accepted that the pathogenesis of cAD involves not only an immunologic component but also a barrier dysfunction. This disruption of normal barrier function leads to increased allergen penetration and sensitization. Thus, the therapeutic ...
Electronegative low-density lipoprotein (LDL) is a recognized factor in the pathogenesis of coronary artery disease (CAD) in the general population, but its role in the development of CAD in uremia patients is unknown. L5 is the most electronegative subfraction of LDL isolated from human plasma. In this study, we examined the distribution of L5 (L5%) and its association with CAD risk in uremia ...
Depression is a well‑established risk factor for cardiac morbidity and mortality in patients with coronary artery disease (CAD). Previous studies have demonstrated that the level of brain‑derived neurotrophic factor (BDNF) is decreased in depressed patients and this depletion may be reversed by antidepressants. Several recent studies have suggested that BDNF is involved in the pathogenesis of C...
Introduction: Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease with still growing incidence among adults and young people worldwide. Patients T2DM are more susceptible to develop coronary artery (CAD) than non-diabetic individuals. Several pre-clinical clinical studies suggested that adiponectin, pleiotropic hormone anti-atherogenic, anti-inflammatory, insulin-sensitizing properti...
BACKGROUND The Asia-specific PLA2G7 994G-T transversion leads to V279F substitution within the lipoprotein-associated phospholipase-A2 (Lp-PLA₂) and to absence of enzyme activity in plasma. This variant offers a unique natural experiment to assess the role of Lp-PLA₂ in the pathogenesis of coronary artery disease (CAD) in humans. Given conflicting results from mostly small studies, a large two-...
Cardiovascular disease (CVD) and depression are two of the most common human health problems. Patients with depression have an increased risk of developing cardiovascular disease and mortality after experiencing a cardiac event. Both diseases are complex disorders that are influenced by genetic and environmental factors. Brain-derived neuro-trophic factor (BDNF) plays a critical role in regulat...
Knowledge of the pathogenesis of coronary artery disease enables associate it with one of possible interrelationships of CAD with the cognitive impairment in the elderly. The chain of atherosclerotic transformations can be the same both in coronary and cerebral vessels. These changes begin from increased endothelial permeability, leucocytes migration into the arterial walls, adherence and aggre...
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