Mouse lemurs are non-human primate models of cerebral aging and neurodegeneration. Much smaller than other primates, they recapitulate numerous features of human brain aging, including progressive cerebral atrophy and correlation between regional atrophy and cognitive impairments. Characterization of brain atrophy in mouse lemurs has been done by MRI measures of regional CSF volume and by MRI m...

Atrophy of the brain due to the death of neurons in Alzheimer’s Disease (AD) is well observed in longitudinal structural magnetic resonance images (MRIs). This thesis focuses on developing a biophysical model able to reproduce changes observed in the longitudinal MRIs of AD patients. Simulating realistic longitudinal MRIs with atrophy from such a model could be used to evaluate brain morphometr...

Background Lifestyle-related risk factors (e.g., smoking) and common health problems hypertension) have been found to be associated with brain atrophy. However, it is still not clear about their independent contribution atrophy, especially among the elderly normal cognition. Here, we aim identify of atrophy in cognitively elderly. Method We included 419 subjects cognition (Table 1) from ADNI da...

BACKGROUND An increased rate of brain atrophy is often observed in older subjects, in particular those who suffer from cognitive decline. Homocysteine is a risk factor for brain atrophy, cognitive impairment and dementia. Plasma concentrations of homocysteine can be lowered by dietary administration of B vitamins. OBJECTIVE To determine whether supplementation with B vitamins that lower level...

Frontotemporal dementia (FTD) accounts for a variable degree of degenerative diseases, ranging between 7 and 15% in different countries, and its symptoms can overlap with those of AD and other dementias. Magnetic resonance (MR) imaging has proved useful in supporting the clinical evaluation during the diagnostic process. Different techniques have been used to quantify brain atrophy on MR images...

UNLABELLED The aim of this study was to investigate if brain atrophy in multiple sclerosis (MS) patients during the disease onset predicts long term disability. METHODS MS patients with follow-up time of at least 7 years from disease onset and with baseline and second magnetic resonance 12 months later were included to measure brain atrophy. Expanded Disability Status Scale (EDSS) was categor...

Background: Increased brain atrophy rates are common in older people with cognitive impairment, particularly in those who eventually convert to Alzheimer disease. Plasma concentrations of omega-3 (v-3) fatty acids and homocysteine are associated with the development of brain atrophy and dementia. Objective: We investigated whether plasma v-3 fatty acid concentrations (eicosapentaenoic acid and ...

Brain atrophy in CT images is often found in patients with Senile dementia of Alzheimer type(AD), but occasionally it isn’t prominent in some patients with symptoms of dementia. On the contrary, some patients with few symptoms of dementia sometimes show a remarkable atrophy in their brain CT. This is one of the reasons why the diagnosis of AD in the early stage is difficult. Therefore, it is ve...

Diffusion Tensor Imaging (DTI) has been a useful technology to examine brain anomalies in relation to white matter atrophy in neurologically impaired patient populations. Of particular interest is using DTI to better characterize brain structure in patients with mental illness or addiction. To that end, the available data show white matter atrophy in brain areas that underlie executive function...