The "carbon nano-world" has made over the past few decades huge contributions in diverse scientific disciplines and technological advances. While dramatic advances have been widely publicized in using carbon nanomaterials such as fullerenes, carbon nanotubes, and graphene in materials sciences, nano-electronics, and photonics, their contributions to biology and biomedicine have been noteworthy ...

My first interest in nuclear magnetic resonance (n.m.r.) spectroscopy began in 1964, when it seemed to me that spectroscopy, and in particular n.m.r., would be a most desirable way to analyse unknowns without smelling everything, or heating with sodium and checking for hydrogen evolution with a match (the classical A-level approach at the time). Unfortunately, I had to wait a couple of years fo...

Alcohol is a well-known cytotoxic agent which causes various kinds of neuronal damage. In spite of thousands of published studies, the true mechanism of alcohol-induced neuronal damage remains unclear. Neurogenesis is the generation of neurons from neural stem cells (NSCs) and occurs in predominantly two regions of the brain, the subventricular zone and the dentate gyrus of the hippocampus. NSC...

Using an orthogonal tRNA-synthetase pair, unnatural amino acids can be genetically encoded with high efficiency and fidelity, and over 40 unnatural amino acids have been site-specifically incorporated into proteins in Escherichia coli, yeast, or mammalian cells. Novel chemical or physical properties embodied in these amino acids enable new means for tailored manipulation of proteins. This revie...

Bubbles induced by blast waves or shocks are speculated to be the major cause of damages in biological cells in mild traumatic brain injuries. Microbubble collapse was found to induce noticeable cell detachment from the cell substrate, changes in focal adhesion and biomechanics. To better understand the bubble mechanism, we would like to construct a system, which allows us to clearly differenti...

The present study was conducted to examine various biological activities of a methanol extract of Agave attenuata leaves. GC-MS analysis of the n-hexane fraction from the extract revealed the presence of 31 compounds, with mono-2-ethylhexyl phthalate (11.37%), 1,2-benzenedicarboxylic acid (6.33%), n-docosane (6.30%) and eicosane (6.02%) as the major components. The leaves contained appreciable ...

Preliminary notes published from this laboratory in the past (Morris and Julianelle, 1935; Julianelle and Pons, 1939a, b; Pons and Julianelle, 1939; and Julianelle, 1940) have dealt summarily with different aspects of the biological and immunological characteristics of the genus Listerella. The data now available after several years of intermittent study bring this phase of the work to a stage ...

This Account is focused on computer simulation studies of model biological membrane systems with potential applications in biomedical research. In the past decade, classical molecular dynamics has provided novel insights into the properties of model biomembrane systems, including the nature of the DNA-lipid interactions, the effect of pore-forming transmembrane peptides on the lipid environment...

Walnut (Juglans regia L.) is a well-known member of the Juglandaceae family and its kernel is widely consumed around the world for both unique nutritional characteristics and health-related benefits. Even though several studies investigated the composition and biological activities of different parts of the walnut tree, the internal septum of the walnut kernel is less evaluated. In the...

Understanding of the factors influencing the spontaneous development and the transplantation of experimental neoplasms has been sought in studies of rat and mouse leukemia. Since leukemia is induced readily in various strains of mice by either carcinogenic hydrocarbons, ionizing radia tions, estrogens, or combinations of these agents (81, 66), the disease has been the subject of recent studies ...