OBJECTIVE To determine the pattern of liver diseases diagnosed in children at Ga-Rankuwa Hospital Histopathology Laboratory. DESIGN A retrospective study. SETTING Ga-Rankuwa Histopathology Laboratory. SUBJECTS Seventy two patients who underwent a liver biopsy during the study period. METHODS Laboratory records were reviewed and all liver biopsies were extracted. All slides were reviewed...

BILIARY atresia is the most common indication for liver transplants in children, and this disorder is associated with some congenital vascular anomalies. Complex vascular anomalies increase the technical difficulties of the operation and previously resulted in high mortality in these patients. The role of the radiologist is to define the conditions in which transplantation is high risk or contr...

Uterine isthmus atresia is a rare Müllerian duct anomaly occasionally diagnosed in adolescents with primary amenorrhea and cyclic abdominal pain. A case presented of 14-year-old female monthly lower pain 2-year duration. Magnetic resonance imaging 3-dimensional ultrasound showed separation 10-mm fibrotic tissue between the cervical canal endometrial cavity. In an attempt to preserve reproductiv...

Biliary innate immunity is involved in the pathogenesis of cholangiopathies in patients with primary biliary cirrhosis (PBC) and biliary atresia. Biliary epithelial cells possess an innate immune system consisting of the Toll-like receptor (TLR) family and recognize pathogen-associated molecular patterns (PAMPs). Tolerance to bacterial PAMPs such as lipopolysaccharides is also important to main...

AIMS To investigate the distribution of alpha and pi class glutathione S-transferases (GST) in normal fetal, neonatal, and adult liver; and to examine changes in GST expression in neonatal liver disease. METHODS alpha and pi class GST were immunolocalised in sections of formalin fixed liver tissue obtained from human fetuses (n = 21), neonates (n = 8), young children (n = 9) and adults (n = 1...

Methods: In 1989, the Japanese Biliary Atresia Society started a nationwide registry, JBAR, to investigate all aspects of biliary atresia. A total of 1,381 patients, 863 girls, 507 boys, and 11 unknown, were registered between 1989 and 1999. JBAR includes an initial and follow-up questionnaires. Using these patients’ data, the incidence, sex distribution, associated anomalies, the type of obstr...

Cholestasis in early infancy represents a diagnostic dilemma and most of these infants suffer either from extrahepatic biliary atresia or idiopathic neonatal hepatitis. Differentiation between the two conditions may be extremely difficult both clinically and biochemically, and a diagnostic liver biopsy is usually required. We report on a Sudanese infant who presented at the age of 4 weeks with ...

Infection of neonatal mice with some reovirus strains produces a disease similar to infantile biliary atresia, but previous attempts to correlate reovirus infection with this disease have yielded conflicting results. We used isogenic reovirus strains T3SA- and T3SA+, which differ solely in the capacity to bind sialic acid as a coreceptor, to define the role of sialic acid in reovirus encephalit...

background: the use of high-dose steroid therapy peri portoenterostomy may have a positive impact on the frequency of cholangitis and survival rate.   methods: a prospective study was conducted on two groups of patients (less than three months of age) suffering from biliary atresia from 1999 to 2005. the patients in group i (g i) were managed peri-operatively by high-dose methylprednisolone whi...