Bicuspid aortic valve (BAV) disease is one of the most frequent observed congenital heart abnormalities affecting 0.5-1.4% of the general population and has a 3:1 male predominance [1-4]. Although some genes have been described that found to be responsible for the abnormal valvulogenesis, little is known about BAV disease with respect to the genetic and embryolog‐ ical insight of calcification ...

We readwith great interest the recent article byWheatley III Grayson et al. on the safety and effectiveness of endovascular repair for primary adult coarctation (PAAC) as an alternative to surgical repair [1]. They report excellent early and midterm results on 16 adult patients with PAAC treated with endovascular repair. The study group included three (18.7%) PAAC patients associated with bicus...

Reptiles have a diverse array of tooth shapes, from simple unicuspid to complex multicuspid teeth, reflecting functional adaptation to a variety of diets and eating styles. In addition to cusps, often complex longitudinal labial and lingual enamel crests are widespread and contribute to the final shape of reptile teeth. The simplest shaped unicuspid teeth have been found in piscivorous or carni...

This study describes the coronary artery distribution patterns associated with the anomalous origin of the left coronary artery from the right side of the aortic valve in Syrian hamsters. The hearts of 15 affected animals were examined by means of a corrosion-cast technique, histology and scanning electron microscopy. The hamsters belonged to a laboratory inbred colony with a high incidence of ...

BACKGROUND Congenital heart disease is the most common type of birth defect, affecting ≈2% of the population. Malformations involving the cardiac outflow tract and semilunar valves account for >50% of these cases predominantly because of a bicuspid aortic valve, which has an estimated prevalence of 1% in the population. We previously reported that mutations in NOTCH1 were a cause of bicuspid ao...

BACKGROUND Dilatation of the ascending aorta in aortic stenosis may be partly explained by intrinsic wall structure changes, but the relative contribution of altered hemodynamics is unclear. The aim of this study was to assess the association between ascending aortic dimensions and valve stenosis severity. METHODS AND RESULTS An analysis of echocardiographic examinations was conducted in 296 ...

Bicuspid aortic valve (BAV) patients are usually excluded from transcatheter implantation (TAVI) as this anatomy likely leads to oval expansion. This study presents a numerical of TAVI using both self-expanding and balloon expandable heart (THV) in bicuspid with severe stenosis. The simulation framework included patient-specific the root, calcifications BAV leaflets extracted medical imaging an...

Bicuspid aortic valve (BAV) represents the most common cardiac congenital malformation in the adult age, with strong male predominance. It may occur in isolation, or in association with other congenital heart diseases. The BAV is seen in 1% to 2% of the population and may be complicated by aortic stenosis or aortic insufficiency and infective endocarditis. It may be associated with abnormalitie...