We present a 25 year follow up of two siblings with autosomal recessive (AR) oculopharyngodistal myopathy. Remarkable in these patients, in comparison with patients with oculopharyngeal muscular dystrophy (OPMD), are the earlier age of onset, severe facial weakness, external ophthalmoplegia early in the course of the disease, and distal weakness in the limbs. Histological features included baso...

Cancer cachexia is a debilitating multi-factorial wasting syndrome characterised by severe skeletal muscle and dysfunction (i.e., myopathy). In the oncology setting, arises from synergistic insults both cancer–host interactions chemotherapy-related toxicity. The majority of studies have surrounded interaction side cancer cachexia, often overlooking capability chemotherapy to induce cachectic my...

THE picture reproduced in Fig. 1 is an unsigned etching dated 4 April 1784, which is firmly attributed on stylistic grounds to Thomas Rowlandson (1756-1827).' The two figures depicted are identified as, on the left the Bethlem mad-doctor John Monro (1715-1791), and on the right the politician Charles James Fox (1749-1806). Dr Monro screws up his right eye as he raises a lens to his left and dec...

A cohort of first-generation Asian immigrants who received a diagnosis of a functional psychosis at the Bethlem Royal and Maudsley Hospitals were compared with an English-born control group. The Asians were found to have spent a lower total percentage of time in the two hospitals, had fewer in-patient admissions per year, and had a shorter average duration of stay in hospital than the matched c...

Background: The TTN gene is related to a broad phenotype spectrum including tibial muscular dystrophy, hereditary myopathy with respiratory failure, limb girdle dystrophy 2J and dilated or hypertrophic cardiomyopathy. In 2014, Chauveau et al, described phenotypes cardiac septal defects, left ventricular non-compaction, Emery-Dreifuss arthrogryposis. 2020, Savarese showed most of patients bialle...

)ften difficult. Often, clinical tésting of the sensory :uflctions is neither reliable nor helpful in the determination. Theoretically, predominant proximal . veakness, neck flexor weakness, and facial weakness occur more often in patients with myopathy. Dn needle electromyography, low amplitudes and short duration of the motor unit potentials suggest myopathy. Normal sensory nerve action poten...

Myopathies related to critical illness have received increasing recognition over the past decade and are common in patients even after a brief period in the intensive care unit. Recent studies have revealed that myopathies in the critically ill may in fact be more prevalent than neuropathies and that morbidity and mortality may be greater. Protein catabolism, an increase in urinary nitrogen los...

REASONS FOR PERFORMING STUDY Fibrotic myopathy can cause incapacitating gait abnormalities. Transection of the fibrotic mass followed by early post operative exercise is the best treatment for fibrotic myopathy. A laser may be used to transect the fibrotic mass. Assessment of the effectiveness of therapies for fibrotic myopathy has been limited to subjective evaluation. OBJECTIVES To objectiv...

Several cases of inflammatory myopathy have been reported during the chronic course of hepatitis C (HC) in recent years. It has been suggested that this muscular inflammatory involvement in HC is related to an immune-mediated mechanism caused by the hepatitis C virus (HCV), as HCV RNA has been detected in the muscle of patients with concomitant inflammatory myopathy and chronic HC. Herein, we r...