The aim of present research was the effect of short-term use of edible solution of jujube one week before a single session of circuit resistance exercise on neutrophil apoptosis of male students of physical education. 14 young male volunteer students were divided into two groups of placebo (n=7, aged 24.50±2.50, height 171.17±1.70, and weight 67.51±4.92) and jujube solution...

This study aimed to investigate whether Opuntia spp-extracts protect against diclofenac (DF)-induced hepatotoxicity. Rats were pretreated with extracts, betanin (Bet) and N-acetylcysteine (NAC) followed by a single challenge of diclofenac. Liver tissue was collected for biochemical histological analysis. Primary rat hepatocytes treated (400 µmol/L) without pretreatment extract. Apoptosis measur...

parkinson's disease is a degenerative disorder of the central nervous system. the motor symptoms of parkinson's disease result from the death of dopamine-generating cells in the substantia nigra, a region of the midbrain the cause of this cell death is unknown. homocysteine (hcy) is a non-protein amino acid. it is a homologue of the amino acid cysteine. the elevated levels of homocysteine in pl...

The aim of the present study was to determine cytotoxic activity of crude methanolicextract of Echinophora platyloba on breast cancer MDA-MB-231 cell line. The free radicalscavenging effects of methanolic extract of E. platyloba were tested using DPPH method.Crude methanolic extract exhibited potential antioxidant activity with an IC50 value of 234.28 ±21.63 μg/mL when compared to the standard ...

Salvia chorassanica Bunge is one of the Iranian endemic species of Salvia. There is not any reported literature on S. chorassanica. This study was designed to examine the in-vitro anti-proliferative and proapoptotic effects of the methanol extract of S. chorassanica and its fractions on HeLa cell line. Cells were cultured in EX-CELL®, an animal free medium specially designed for HeLa cell line ...

The aim of the present study was to determine cytotoxic activity of crude methanolicextract of Echinophora platyloba on breast cancer MDA-MB-231 cell line. The free radicalscavenging effects of methanolic extract of E. platyloba were tested using DPPH method.Crude methanolic extract exhibited potential antioxidant activity with an IC50 value of 234.28 ±21.63 μg/mL when compared to the standard ...

Abstract Background Inhibition of nuclear import via Karyopherin beta 1 (Kpnβ1) shows potential as an anti-cancer approach. This study investigated the use inhibitor, INI-43, in combination with cisplatin. Methods Cervical cancer cells were pre-treated INI-43 before treatment cisplatin, and MTT cell viability apoptosis assays performed. Activity localisation p53 NFκB was determined after co-tre...

Rac proteins, members of the Rho family small GTP-binding have been implicated in transducing a number signals for various biological mechanisms, including cell cytoskeleton organization, transcription, proliferation, migration, and cancer motility. Among human cancers, proteins are highly activated by either overexpression genes, up-regulation protein, or mutations that allow protein to elude ...