Patients with chronic renal failure (CRF) have a high incidence of tuberculosis (TB). Those from the Indian subcontinent are at particular risk. The frequency of side-effects associated with antituberculous treatment in a group of patients with CRF was studied. All cases of TB in patients with CRF occurring over a 13-yr period at the Manchester Royal Infirmary, from 1986-1999, were identified b...

We report a rare case of obstructive jaundice caused by a tuberculous abscess in the head of pancreas, mimicking carcinoma. The case was successfully treated by pylorus-preserving proximal pancreatoduodenectomy and antituberculous drugs.

BACKGROUND In recent years, the impact of antituberculous treatment on interferon (IFN)-gamma response to Mycobacterium tuberculosis antigens has been widely investigated, but the results have been controversial. The objective of the present study was: i) to evaluate longitudinal changes of IFN-gamma response to M. tuberculosis-specific antigens in TB patients during antituberculous treatment b...

BACKGROUND We report a rare presentation of extrapulmonary tuberculosis. CASE PRESENTATION A 29-year-old Burmese woman with human immunodeficiency virus infection and known pulmonary tuberculosis who had been treated for 5 months presented to our hospital with unilateral progressive painful visual loss of 1 month's duration. She was diagnosed with tuberculous panophthalmitis with subretinal a...

BACKGROUND It has been suggested that Mycobacterium paratuberculosis is the cause of Crohn's disease. In a previous report the immediate effect of two years treatment with antituberculous chemotherapy showed no clinical benefit. AIMS To assess both the immediate and longer term effect of treatment on the disease. METHODS Patients were followed for five years from their date of entry to the ...

Resistance to antituberculous agents is an important cause of ineffectiveness of antimicrobial therapy. The resistance of M. tuberculosis to antituberculous agents is a result of mutations in genes participating in those agent's action. The antituberculous drug--isoniazid can be activated by Mycobacterium tuberculosis either through a hydroperoxidase I/II or a superoxide-dependent oxyferrous pa...

Bronchogenic cyst is a common primary of the mediastinum, and it usually located in middle mediastinum intrapulmonary regions. cysts are lesions congenital origin that occur due to abnormal budding from primitive ventral foregut. They pediatric age group have symptoms respiratory distress, recurrent cough, wheezing, stridor. Definitive management involves surgical excision. We herein report our...

In this issue of the BJD, Ye et al.1 present data on T-cell-specific responses in patients with antituberculosis drug (ATD)-induced maculopapular exanthema (MPE) and drug reaction with eosinophilia and systemic symptoms (DRESS). Understanding these responses helps further our knowledge of the immunopathogenesis of antituberculous hypersensitivity, and ideally it would be translated into diagnos...