Drug rash with eosinophilia and systemic symptoms syndrome (DRESS) is a rare but serious hypersensitivity drug reaction most frequently associated antiepileptics. We report case of carbamazepine-induced DRESS in 61-year-old man who was recently initiated on carbamazepine (6 weeks back) presented history acute febrile illness 10 days duration. General examination showed multiple erythematous coa...

OBJECTIVE This paper reveals the studies of carbamazepine monitoring in the manifestation of side effects during clinical use. It is important to realize that these ranges are derived statistically, with most patients who have high levels suffering side effects and some with poor control having low levels. Broadly, the newer agents have advantages of lower risk of side effects and less drug int...

The active substances in the drug can cause various negative effects by accumulating ecosystem. Many of medications are resistant to biodegradation, which given recipient media conventional wastewater treatment plants, partially or no purification. In this study, 13 different pharmaceutical compounds belonging classes anti-depressants, antiepileptics, anti-inflammatories, beta-blockers, licodai...

Nefopam is a centrally acting non-opioid analgesic with a mechanism of action that is not completely understood. Adverse effects associated with the therapeutic use and overdose of nefopam are mainly associated with the central nervous system, such as hallucinations, cerebral edema and convulsions. The aim of this study was to assess the effect of nefopam on the electrical threshold and its inf...

Many investigators reported that the hippocampus (HPC) was involved in cerebral and cerebellar seizure discharges and epileptiform phenomena (1-4), and it was the well known site of histological lesion which was found in approximately 50 per cent of epileptic brains (5, 6). The HPC has the lowest threshold of excitability to electrical stimulus of all the cerebral structues so far studied since...

Introduction: Visceral leishmaniasis, a tropical infectious disease, is a major public health problem in India. Tuberous sclerosis, a congenital neuro-ectodermosis, is an uncommon disease which requires life long treatment. Case presentation: A 15-year-old Indian patient, presented to the outpatient department of our institute with a high-grade fever for two months, splenomegaly and a history o...