"Nutritional supplements" that promise an increase in muscle mass and strength are becoming a go to item as enhancing one's physical appearance becomes a more important part of our society. This is alarming because many of these nutritional supplements rely on androgen precursors to deliver their promises, without adequately informing consumers of the potential side effects of such agents. Thes...

Most patients with bone metastases experience skeletal complications, resulting in significant morbidity and increased risk of death. Although the use of bisphosphonates is a well-established form of supportive care treatment for bone metastasis, complications arising from long-term use require schedule optimization and a search for alternative strategies. Moreover, the scope of use of bone-tar...

OBJECTIVE To develop a clear, concise, and up-to-date treatise on the role of anabolism from nutrition in wound healing. Special emphasis was to be placed on the effect of the stress response to wounding and its effect. METHODS A compilation of both the most important and most recent reports in the literature was used to also develop the review. The review was divided into sections to emphasi...

OBJECTIVES To examine the attitudes to, and knowledge of, doping in sport of French general practitioners (GPs), and their contact with drug taking athletes on an everyday basis. METHODS A total of 402 GPs were randomly selected from all over France and interviewed by telephone, using a prepared script. RESULTS The response rate was 50.5% (153 men and 49 women; mean (SD) age 45.6 (5.6) year...

wnloade st patients with bone metastases experience skeletal complications, resulting in significant morbidd increased risk of death. Although the use of bisphosphonates is a well-established form of supe care treatment for bone metastasis, complications arising from long-term use require schedule ization and a search for alternative strategies. Moreover, the scope of use of bone-targeted agent...

BACKGROUND Parathyroid hormone-related protein (PTHrP) has anabolic effects in bone, which has led to the clinical use of N-terminal fragments of PTHrP and PTH. Since 10% to 20% of fractures demonstrate healing complications and osteoporosis continues to be a debilitating disease, the development of bone-forming agents is of utmost importance. Due to evidence that regions of PTHrP other than th...

(1) Background: Recently, Escherichia coli-derived recombinant human bone morphogenetic protein-2 (E. rhBMP-2) has been increasingly applied to different types of spinal surgeries and reported achieve successful fusion. This pilot study aimed evaluate the clinical efficacy safety rhBMP-2 in patients undergoing posterior instrumented fusions for unstable fractures. (2) Methods: included ten cons...

According to the regulations of the World Anti-Doping Agency (WADA) [1], anabolic androgenic steroids are classified as prohibited substances in sports. They are covered in the section “S1. Anabolic Agents 1. Anabolic Androgenic Steroids (AAS)”. This section is further subdivided into “a. Exogenous AAS” and “b. Endogenous AAS”. AAS represent the class of substances most frequently detected in h...

We aimed to identify novel molecular mechanisms for muscle growth during administration of anabolic agents. Growing pigs (Duroc/(Landrace/Large-White)) were administered Ractopamine (a beta-adrenergic agonist; BA; 20 ppm in feed) or Reporcin (recombinant growth hormone; GH; 10 mg/48 hours injected) and compared to a control cohort (feed only; no injections) over a 27-day time course (1, 3, 7, 1...