Relationships are unclear between polymorphisms in genes involved in metabolism and detoxification of various chemicals and papillary thyroid cancer (PTC) risk as well as their potential modification by alcohol or tobacco intake. We evaluated associations between 1647 tagging single nucleotide polymorphisms (SNPs) in 132 candidate genes/regions involved in metabolism of exogenous and endogenous...

BACKGROUND/AIMS Whether alcohol intake increases the risk of hepatocellular carcinoma (HCC) in patients with chronic hepatitis B virus (HBV) infection remains controversial. The aim of this study was to determine the effect of alcohol intake on the development of HCC. METHODS Between January 2006 and August 2008, 146 patients with an initial diagnosis of HCC who were hospitalized in 3 major h...

BACKGROUND Moderate alcohol intake has been associated with lower cardiovascular mortality. However, data evaluating the relationship between C-reactive protein (CRP), a predictor of cardiovascular risk, and alcohol consumption are sparse. METHODS AND RESULTS The relationship between alcohol consumption and CRP was evaluated in a cross-sectional survey and over time among 1732 men and 1101 wo...

Increased thickness and stiffness of large arteries may contribute to why aging is the most important risk for cardiovascular diseases. Arterial stiffness, intimal medial thickness, and alcohol intake were measured in 563 subjects. A U-shaped relation was found between alcohol intake and a stiffness index, with the lowest index in moderate drinkers, which may partially explain the relation betw...

background: in this study, we examined the status of korean women’s alcohol consumption and identified the physical changes they undergo according to the level of consumption. the results of this study may thus be used as raw data to effectively control women’ drinking habits. methods: this study consists of a secondary analysis using data from female participants in the 6 th korea national hea...

BACKGROUND Numerous studies have documented the negative effects of maternal alcohol consumption during pregnancy on risk of pregnancy loss, yet whether prepregnancy alcohol intake affects the risk of spontaneous abortion is still unclear. OBJECTIVE This study aimed to assess prepregnancy alcohol intake and risk of spontaneous abortion and stillbirth. METHODS Our prospective cohort study in...

BACKGROUND Alcohol intake has been associated with the bitter taste receptor T2R38. TAS2R38 gene expresses two common haplotypes: PAV and AVI. It has been reported that AVI homozygotes consume more alcohol than heterozygotes and PAV homozygotes. The aim of this study was to determine the prevalence of the TAS2R38 haplotypes among Mexican-Mestizo population and to analyze its association with al...

The study aimed to estimate the prevalence of smoking and alcohol intake among university students from the Federal University of Pelotas, Brazil (UFPel), as well as to investigate factors associated with both habits. The sample included 485 students who were admitted to the university in 2008. Students were sampled randomly across all schools of the UFPel campus, and answered a pre-tested ques...

Many epidemiological studies have demonstrated a correlation between alcohol intake and the occurrence of cancer in humans. All types of alcoholic beverages are associated with an increased risk which suggests that ethanol itself is the crucial compound which causes that effect.The International Agency for Research for Cancer classified alcohol consumption and acetaldehyde associated with alcoh...

Over the past few years, advances in the investigation of the neurochemical circuits involved in the development and treatment of alcohol dependence have identified peptides and receptors as potential key targets in the treatment of problems related to alcohol consumption. The endogenous opioid system is modified by alcohol intake in areas of the brain related to reward systems, and differentia...