1 Pindolol is a ,B-adrenoceptor antagonist equally effective on land P2-adrenoceptors which has a relatively long duration of action. It is practically completely absorbed and, unlike most other P-adrenoceptor blockers, is only metabolized to a small extent during the first passage through the liver. 2 Pindolol possesses partial agonist activity (intrinsic sympathomimetic activity, ISA). This m...

1 The subtypes of alpha1-adrenoceptor mediating contractions of rat vas deferens to endogenous and exogenous noradrenaline and to the exogenous agonists methoxamine, phenylephrine and A61603 have been examined. 2 The effects of antagonists on the shape of concentration-response curves, both tonic and phasic, to the four agonists were analysed. Prazosin produced parallel shifts in all cases. Par...

Van der Heijden, H. F. M., L. M. A. Heunks, H. Folgering, C. L. A. van Herwaarden, and P. N. R. Dekhuijzen. b2-Adrenoceptor agonists reduce the decline of rat diaphragm twitch force during severe hypoxia. Am. J. Physiol. 276 (Lung Cell. Mol. Physiol. 20): L474–L480, 1999.—The aim of the present study was to investigate the in vitro effects of the short-acting b2-adrenoceptor agonist salbutamol ...

Ipratropium bromide is an anticholinergc bronchodilator administered by inhalation. Although producing bronchodilation in most patients with obstructive airways disease, it is somewhat less effective than beta 2-adrenoceptor agonist drugs such as salbutamol or fenoterol in patients with asthma, but is at least as effective as these agents in bronchitis. As with the beta 2-adrenoceptor agonists,...

In 1990 we reported a randomized controlled trial in which the administration of regular inhaled β2-agonist therapy was associated with a deterioration in asthma control in a majority of subjects when compared to as-required β-agonist treatment [1]. There were more asthma exacerbations, reductions in the forced expiratory volume in one second (FEV1) and morning peak expiratory flow rates (PEFRs...

In this study, three lines of evidence suggest a role for α(2)-adrenoreceptors in rat pup odor-preference learning: olfactory bulb infusions of the α(2)-antagonist, yohimbine, prevents learning; the α(2)-agonist, clonidine, paired with odor, induces learning; and subthreshold clonidine paired with subthreshold β-adrenoceptor activation also recruits learning. Increased mitral cell layer pCREB o...