Administration of apomorphine and amphetamine induces climbing behavior in mice due to stimulation of brain dopamine receptors. In the present study, the effects of adrenoceptor agonists and antagonists on amphetamine-induced climbing have been investigated. Intraperitoneal (i.p.) injection of different doses of amphetamine (2,4 and 8 mglkg) induced climbing in mice (p<O.OOO 1). The u2- ad...

in this study, the effect of α-adrenoceptor agents on imipramine-induced antinociception was investigated using formalin test. intraperitoneal (i.p.) administration of imipramine at different doses (10-80 mg/kg) induced antinociception in both phases of formalin test. in addition, intracerebroventricular (i.c.v.) injection of imipramine (1, 5, and 10 µg/rat) did not elicit any effect, although ...

a 25-year-old afghan male was presented to the emergency department with femoral shaft fracture following fall from the height. the patient was subjected to femoral nerve block and general anesthesia. first try for performing nerve block led to vascular puncture. therefore, the needle was removed and re-inserted 1 cm lateral to first puncture site and dex injected slowly with aspiration check a...

We proposed that mitral cell 1-adrenoceptor activation mediates rat pup odor preference learning. Here we evaluate 1-, 2-, 1-, and 2-adrenoceptor agonists in such learning. The 1-adrenoceptor agonist, dobutamine, and the 1-adrenoceptor agonist, phenylephrine, induced learning, and both exhibited an inverted U-curve dose-response relationship to odor preference learning. Phenylephrine-induced le...

In this study, the effect of α-adrenoceptor agents on imipramine-induced antinociception was investigated using formalin test. Intraperitoneal (i.p.) administration of imipramine at different doses (10-80 mg/kg) induced antinociception in both phases of formalin test. In addition, intracerebroventricular (i.c.v.) injection of imipramine (1, 5, and 10 µg/rat) did not elicit any effect, although ...

It has been shown that inflammation reduces the effectiveness of sympathetic nerves in the regulation of knee joint blood flow, and the joint vascular- ß adrenoceptors are changed due to acute inflammation from a majority of ß-1 to an equality of ß-1 and ß-2 receptors.. To investigate the role of sympathetic nerves in nerve induced vasoconstriction and changes in joint vascular ß-adrenoceptors ...

the internal mammary artery (ima) is currently the preferred conduit for myocardial revascularization. however, pre-operative vasospasm and a hypoperfusion state during maximal exercise may limit its use as a bypass graft. the mechanism of spasm has not been clearly defined. since β-adrenoceptor activation plays a major role in vasorelaxation, the present study was carried out to investigate th...

1. Noradrenaline stimulates gluconeogenesis through an (a-adrenoceptor in renal cortical tubule fragments from fed rats incubated with 5 mM-lactate. 2. The selective a1-adrenoreceptor agonist methoxamine stimulated gluconeogenesis, but the selective a2-adrenoceptor agonist clonidine was ineffective. 3. The selective a1-adrenoceptor antagonist thymoxamine blocked the stimulatory effects on gluco...

The internal mammary artery (IMA) is currently the preferred conduit for myocardial revascularization. However, pre-operative vasospasm and a hypoperfusion state during maximal exercise may limit its use as a bypass graft. The mechanism of spasm has not been clearly defined. Since β-adrenoceptor activation plays a major role in vasorelaxation, the present study was carried out to investigate th...

The effect of 24-h pretreatment with epinephrine (EPI) or norepinephrine (NE) on alpha(2)- and beta-adrenoceptor agonist-induced, cAMP responses and G(i3)alpha-protein expression was studied in primary cultures of rat superior cervical ganglionic (SCG) neurons. SCG neurons, 10 to 12 days in culture, accumulated cAMP when stimulated with the beta-adrenoceptor agonist isoproterenol and the prefer...