influenza is a contagious viral disease that is seen in avian, human and other mammals, so its control is important. vaccination against influenza virus subtype h9n2 is one of the ways in controlling program, for this reason several vaccines has been produced. recently, application of inactivated oil-emulsion vaccines in poultry for controlling low pathogenic avian influenza is increasing. at p...

the immune responses of mice immunized with ovalbumin (ova) together with killed l. major (klm) promastigotes as adjuvant were studied. three doses (5 × 107, 1 × 108 and 2 × 108) of klm combined with ova (100 mg) were injected into the groups of c57bl/6 mice. bcg and complete freund’s adjuvant (cfa) were used as control adjuvants. lymphocyte proliferation and antibody titers were determined, an...

background: heat shock proteins (hsp) are highly conserved molecules with many immunological functions. they are highly immunogenic with important role in cancer immunotherapy and in vaccine development against infectious diseases. as adjuvant, hsp can augment the immunogenicity of weak antigens and can stimulate antigen presenting cells. although vaccines have been successful for many infectio...

Abstract γδ T cells are ideal effector against cancer and pathogens for numerous reasons: they found in blood, mucosa, lymphoid organs, develop memory responses independent of MHC restriction, present antigen, produce cytokines, cytolytic. An obstacle the development biomedical interventions targeting is need an adjuvant that promotes their expansion suitable human use. The routinely used, IL-2...

The development of safe and effective vaccines for avian influenza viruses is a priority for pandemic preparedness. Adjuvants improve the efficacy of vaccines and may allow antigen sparing during a pandemic. We have previously shown that influenza virus-like particles (VLPs) comprised of HA, NA, and M1 proteins represent a candidate vaccine for avian influenza H9N2 virus [Pushko P, Tumpey TM, F...

In the present study the effect of the locally produced genetic adjuvant of ginea pig specific CpG-motif-containing oligodeoxynucleotide (CpG-ODN) in an inactivated FMD virus vaccine was evaluated. Boosting the ginea pigs with FMD vaccine along with CpG-ODN adjuvant produced relatively higher ratio (5-fold) of FMDV-specific IgG2a / IgG1 than those vaccinated in the absence of CpG-ODN. The neutr...

Serine-proteases are important players in the pathogenesis of asthma, promoting inflammation and tissue remodeling. It's also known that many serine protease inhibitors display immunomodulatory properties. TgPI-1 is a Toxoplasma gondii protein that exhibits broad spectrum inhibitory activity against serine proteases. In view of the increased prevalence of atopic disorders and the need to develo...

BACKGROUND With the exception of some live vaccines, e.g. BCG, subunit vaccines formulated with "classical" adjuvants do not induce similar responses in neonates as in adults. The usual neonatal profile is characterized by lower levels of TH1-associated biomarkers. This has hampered the development of new neonatal vaccines for diseases that require early protection. Tuberculosis is one of the m...

OBJECTIVES Esculetin (6,7-dihydroxycoumarin) is a natural coumarin with anti-oxidant, anti-inflammatory and anti-nociceptive activity. It acts as a potent inhibitor of lipoxygenases (5-LOX and 12-LOX) and decreases the production of matrix metalloproteinases (MMP-1, MMP-3 and MMP-9). Because both inhibition of lipoxygenases and inhibition of matrix metalloproteinases are effective strategies in...