introduction: gtpase regulator associated with focal adhesion kinase (graf) is a recently identified gtpase activating protein that has the tumor suppressor properties. however, the expression level of graf in leukemia had received less attention. the main purpose of this research was the evaluating of the expression level of graf in patients with acute myeloid leukemia (aml). materials and met...

tlte usual manifestation of acute promyelocyte leukemia is hemorrliagic tendency hut thrombotic manifestations may dominate the clinical picture. we report a patient with promyelocyte leukemia which presented as thrombotic cerebrovascular accident and responded to all-transretionic acid and chemotherapy.

Cutaneous presentation revealing acute myeloid leukemia (AML) is rare, and the prognosis poor. We report a case of an 11-month-old male who presented with cutaneous lesions present as diffuse purplish papulo-nodular lesions, M5 leukemia. Skin biopsy immunohistochemical examination, combined routine blood analysis bone marrow contributed to early diagnosis. However, despite intensive chemotherap...

two igm monoclonal antibodies (mab) with strong reactivity for granulocytes and to a lesser extent for lurkat cell lines were established by immunizing balbi c mice with a histiocytic cell line (uy37). these two mabs (designated as 6c9 and 4c4) reacted with blast cells of t-acute lymphoblastic leukemia (t-all) and acute myelogenous leukemia (aml) patients as well as leukemic cells from patients...

hypercalcemia complicating malignancy is a rare complication in pediatric age group. in this article, we present a case with acute lymphoblastic leukemia presenting as severe hypercalcemia. a 10 years old girl presented with an acute onset of fever, nausea, vomiting, loss of weight, costovertebral pain and frequency. she was admitted with a presumptive diagnosis of acute pyelonephritis. her exa...

acute leukemia is the most common malignancy in childhood, which mainly involves children less than 15 years of age. the growing skeleton is the main site of involvement in children. leukemic cells proliferate within the massive red bone marrow in children. so besides the pallor, petechia, purpura and ecchymosis in the skin and mucosal surfaces, bone pain and other bony lesions are other manife...

purpose: to report an unusual ocular presentation of a relapse of acute lymphoblastic leukemia. case report: a 9-year-old girl presented with a subconjunctival mass and ipsilateral preauricular lymphadenopathy. she had history of acute lymphoblastic leukemia (all) in remission but had a normal blood cell profile. because of corneal dellen formation and enlargement of the mass over a 2-week peri...

acute lymphoblastic leukemia (all) is the most common form of childhood cancer representing 80-85% of all leukemia. we describe a 3 years old girl with pain, swelling and tenderness in extremities since 8 months prior to her present admission. x-ray of extremities revealed callus formation, osteopenia and site of healed fractures. bone marrow aspiration revealed all-l2 with normal peripheral sm...

Background: Previous studies have pointed to the major role of viruses in pathogenesis cancers, especially lymphoproliferative cancers. Objectives: The current study investigated relationship between recent Human Herpesvirus Type 6 (HHV6) infection and childhood leukemia-lymphoma syndrome. Methods: From January 2011 December 2012, we entered every new case acute lymphoblastic leukemia, non-Hodg...

Acute myelogenous leukemia (AML) is a hematological malignancy, which accounts for about 15-25% of childhood's leukemia. Genetic factor is one of the most important predisposing elements in childhood acute leukemia, especially AML. In this case report, a rare presentation of familial AML is presented in three monozygotic triplets. Two were 10 months old, and the other one was 16 months old at p...