Biologically, Acute myeloid leukemia (AML) is highly heterogenous. AML with cup-like blast morphology variant has been reported to have important role in risk group stratification and treatment implications. In pediatric age group, this morphology and its clinical implication is rarely discussed. Although this morphology variant is not stated in World Health Organization (WHO) classification of...

BACKGROUND In nondiabetic patients with ST-segment-elevation myocardial infarction, acute hyperglycemia is associated with adverse outcome. Whether this association is due merely to hyperglycemia as an acute stress response or whether longer-term glycometabolic derangements are also involved is uncertain. It was our aim to determine the association between both acute and chronic hyperglycemia (...

background:modafinil, a non-amphetamine central nervous system stimulant, is a wakefulness-promoting agent indicated for use in shift work sleep disorder, narcolepsy, and obstructive sleep apnea. the trend in modafinil overexposure over a ten-year period and the population likely to experience a resulting clinical effect is evaluated. methods: using data from the american association of poison ...

OBJECTIVES The purpose of this study was to examine the impact of sulfonylurea drug use on outcome in diabetic patients undergoing direct coronary angioplasty for acute myocardial infarction. BACKGROUND Sulfonylurea drugs impair ischemic preconditioning. Whether sulfonylurea drugs affect outcome adversely in diabetic patients undergoing direct angioplasty for acute myocardial infarction is un...

BACKGROUND AND PURPOSE Amphetamine is reported to enhance recovery after experimental stroke, but results from the first few trials in humans are inconclusive. Limited information is available on treatment safety. This study intended to investigate the safety and tolerability of dexamphetamine in patients with acute cerebral ischemia. METHODS Forty-five patients with cerebral ischemia were en...

Introduction Previous studies identifying predictors for transmural infarction in patients with ST-elevation myocardial infarction (STEMI) reperfused by primary percutaneous intervention (PCI), especially analyzing the time-dependency of transmural infarction, achieved inconsistent results and are limited due to small and highly-selected study samples. Furthermore it remains unclear whether tra...

OBJECTIVES This study was designed to determine predictors of restenosis after successful percutaneous mitral commissurotomy (PMC) and its relationship to late clinical outcome. BACKGROUND The restenosis rate after PMC and its relationship to late clinical outcome is poorly defined. METHODS Serial echocardiography was performed in 310 patients who underwent PMC. Restenosis, defined as mitra...

Middle East Respiratory syndrome (MERS) first emerged in Saudi Arabia in 2012 and remains a global health concern. The objective of this study was to compare the clinical features and risk factors for adverse outcome in patients with RT-PCR confirmed MERS and in those with acute respiratory disease who were MERS-CoV negative, presenting to the King Fahad Medical City (KFMC) in Riyadh between Oc...