Growth of Salmonella enterica serovar Typhimurium strain 14028 with myo-inositol (MI) is characterized by a bistable phenotype that manifests with an extraordinarily long (34 h) and variable lag phase. When cells were pre-grown in minimal medium with MI, however, the lag phase shortened drastically to eight hours, and to six hours in the absence of the regulator IolR. To unravel the molecular m...

During signaling by the Notch receptor, Notch’s intracellular domain is cleaved, moves to the nucleus and associates with a DNAbinding protein of the CSL class (CSL for CBF1, Suppressor of Hairless (Su(H)), LAG-1); as a result, target genes are transcriptionally activated (reviewed in [1,2]). In Caenorhabditis elegans, a glutamine-rich protein called LAG-3 forms a ternary complex with the Notch...

During signaling by the Notch receptor, Notch’s intracellular domain is cleaved, moves to the nucleus and associates with a DNAbinding protein of the CSL class (CSL for CBF1, Suppressor of Hairless (Su(H)), LAG-1); as a result, target genes are transcriptionally activated (reviewed in [1,2]). In Caenorhabditis elegans, a glutamine-rich protein called LAG-3 forms a ternary complex with the Notch...

We present a new stabilization approach for nonlinear plants with a long input delay. The stabilization problem is complicated by the influence of an uncertain biased sinusoidal disturbance. The problem of control design is solved with using measurable state variables. The adaptive scheme allows to identify the frequency and other parameters of the external disturbance that are used in a reject...

The paper is concerned with application of mathematical modeling to the analysis of signaling pathways. Two issues, deterministic modeling of gene transcription and model-driven discovery of regulatory elements, are dealt with. First, the biological background is given and the importance of the stochastic nature of biological processes is addressed. The assumptions underlying deterministic mode...

The influence of oxygen and temperature on the inactivation of pyruvate, Pi dikinase and NADP-malate dehydrogenase was studied in Zea mays. O(2) was required for inactivation of both pyruvate, Pi dikinase and NADP-malate dehydrogenase in the dark in vivo. The rate of inactivation under 2% O(2) was only slightly lower than that at 21% O(2). The in vitro inactivation of pyruvate, Pi dikinase, whi...