Congenital generalized lipodystrophy (CGL) is a rare autosomal recessive disorder characterized by near complete absence of adipose tissue since birth and insulin resistance. The diagnosis is made on the basis of lack of body fat, muscular hypertrophy, acanthosis nigricans, hirsutism, hepatomegaly with fatty liver, hyperlipidemia and hyperglycemia with insulin resistance. We describe a 4-year-o...

BACKGROUND AND PURPOSE Jugular foraminal stenosis (JFS) or atresia (JFA) with collateral emissary veins (EV) has been documented in syndromic craniosynostosis. Disruption of EV during surgery can produce massive hemorrhage. Our purpose was to describe the prevalence of prominent basal emissary foramina (EF), which transmit enlarged EV, in syndromic craniosynostosis. Our findings were correlated...

None of them reported any illness or habitual use of medication. We observed that all 3 patients examined presented small stature, with short limbs. The patient reported that all except 1 of her siblings were of small stature, as was 1 of her children. Radiological examinations of the patient revealed shortened long bones diagnostic of hypochondroplasia and similar results were seen in her son....

Background: In this study we compared the clinical and biochemical variables of adolescent females with PCOS (polycystic ovarian syndrome) its association or without acanthosis nigricans (AN).Methods: Adolescent girls (14-19 years) oligomenorrhoea hyperandrogenism were studied. Clinical parameters like blood pressure (BP), body mass index (BMI), abdominal circumference (AC), presence absence ac...

Correspondence Figure 1. Acanthosis nigricans in the axilla of a patient receiving treatment with protease inhibitors. Sir—Dubé [1] and Thiébaut et al. [2] have published interesting articles describing insulin resistance in patients with HIV infection who are receiving treatment with protease inhibitors. Recently , an increasing number of papers have been published which relate treatment with ...