Mammalian olfactory sensory neurons (OSNs) form the primary elements of the olfactory system. Inserted in the olfactory mucosa lining of the nasal cavity, they are exposed to the environment and their lifespan is brief. Several reports say that OSNs are regularly regenerated during the entire life and that odorant environment affects the olfactory epithelium. However, little is known about the ...

Studies are described on the phase I and II metabolism and the toxicological analysis of the piperazine-derived designer drug 1-(3-trifluoromethylphenyl)piperazine (TFMPP) in rat urine using gas chromatography/mass spectrometry (GC/MS) and liquid chromatography/mass spectrometry (LC/MS). The identified metabolites indicated that TFMPP was extensively metabolized, mainly by hydroxylation of the ...

The title compound, C(23)H(23)ClN(2)O(2)S, was synthesized by the nucleophilic substitution of 1-benzhydrylpiperazine with 4-chloro-phenyl-sulfonyl chloride. The piperazine ring is in a chair conformation. The geometry around the S atom is that of a distorted tetra-hedron. There is a large range of bond angles around the piperazine N atoms. The dihedral angle between the least-squares plane (p1...

We have designed imidazolium and piperazinium salts of pyropheophorbide-a in order to develop effective photosensitizers which have good solubility in polar and non polar media and to reveal the possible influences of the piperazine and imidazole moieties on the biological activities of pyropheophorbide-a. The phototoxicity of those pyropheophorbide-a salts against A549 cells was studied in vit...

A series of new 4-(5-(3-cyano-4-isobutoxyphenyl)-4-methylthiazole-2-carbonyl)-N-(substituted phenyl)piperazine-1-carboxamides 8(a-e)/carbothioamides 8(f-j) were accomplished for biological interest by the simple addition of active functionalized arylisocyanates 7(a-e)/arylisothiocyanates 7(f-j) with 2-isobutoxy-5-(4-methyl-2-(piperazine-1-carbonyl)thiazol-5-yl)benzonitrile (4). Compound 4 was s...

Myrcia is one of the largest genera of the economically important family Myrtaceae. Some of the species are used in folk medicine, such as a group known as "pedra-hume-caá" or "pedra-ume-caá" or "insulina vegetal" (insulin plant) that it is used for the treatment of diabetes. The species are an important source of essential oils, and most of the chemical studies on Myrcia describe the chemical ...

In the title mol-ecular salt, (C10H16N2)[CoCl4], the piperazine ring of the phenyl-piperazine dication adopts a chair conformation and the phenyl ring occupies an equatorial orientation. In the tetra-chlorido-cobaltate(II) dianion, the Co-Cl bond lengths for the chloride ions not accepting hydrogen bonds are significantly shorter than those for the chloride ions accepting such bonds. In the cry...

Benzocycloheptapyridine tricyclic compounds with piperazine or substituted piperidine moieties extending either from the 5- or 6-position of the tricyclic bridgehead exhibited enhanced FTase activity: this resulted from favorable binding of the ligand nitrogen with the catalytic zinc found in the FTase. A single isomer at C-11 with piperazine adduct extending from the 6-position, compound 24, e...

In the present work two new analytical methods, a gravimetric and a spectrophotometric, for the assay of piperazine free base and its soluble salts in the anthelmitic preparation "Oxyuran", are described. Both approaches are based on the quantitative reaction between the diprotonated cationic form of piperazine and the 3-methyl-4-nitro-1-p-nitrophenyl-5-pyrazolone (picrolonic acid), in sulfuric...

Binuclear Cobalt(II) complexes of the type [Co2(pipdtc)(aa)2(H2O)4], containing bridging Piperazine Dithiocarbamate (pipdtc) and amino acids(aaH) such as alanine(alaH), Phenyl alanine(phealaH), Tyrosine(tyrH), Methionine(metH) and Glycine(glyH) as the deprotonated chelated anion , have been prepared and Characterized by elemental and thermal analysis, IR, UV-Vis , ESR spectral studies, and magn...