In vitro antimicrobial activity of seventeen heterocyclic nitrogen compounds {2-substituted pyrido [1,2-a] pyrimidin -4-oxo-1 [4]-3-Carbonitriles and ethyl 5-amino-3-(substituted) - pyrazole-3-Carboxylates} was tested against Escherichia coli, Bacillus subtilis and candida albicans strains, Antimicrobial activity was measured using standard two -fold serial dilution method and the minimum inhib...

2,2'-disubstitutedamino-4-4'-bis-pyrimidines (3a-m) have been prepared by linking 2,4-dichloro-6-methyl-5-nitropyrimidine (1) with several diamines and subsequent reaction with suitable amines. some of these compounds (3c and 3j) which were reduced catalitically, on treatment with nitrous acid, urea in pyridine, and boiling thionyl chloride gave the corresponding bistriazolopyrimidin ...

Developing DNA‐encoded libraries of privileged scaffolds, such as pyrrolopyrimidines, is great interest in drug discovery and chemical biology a powerful tool to rapidly inexpensively discover potent candidates. However, it often challenging construct because many reaction conditions are not compatible with DNA. Here, we describe the development convenient solid‐phase synthetic strategy that ov...

Carcinostatic activity of 4-(substituted amino)-pyrasolo(3,4-d pyrimidines was found to be confined to compounds whose basic dissociation constants approximated that of adenine (1, 2). In addition, the toxicity of 4-aminopyrazolo(3,4d)pyrimidine could be reversed by adcnine or adenine-containing compounds in a number of biological systems (1, 3-7). These findings led to the hypothesis that the ...

The three possible structural isomers of 4-(pyridyl)pyrimidine were employed for the synthesis of new pyrrolo[1,2-c]pyrimidines and new indolizines, by 1,3-dipolar cycloaddition reaction of their corresponding N-ylides generated in situ from their corresponding cycloimmonium bromides. In the case of 4-(3-pyridyl)pyrimidine and 4-(4-pyridyl)pyrimidine the quaternization reactions occur as expect...

A series of new 3-formyl coumarine (2) was synthesized in good yields by replacement of chlorine atom by 2 amines. In addition, 5-chromeno-pyrido[2,3-d]pyrimidine-4-yl derivatives (5,6) was synthesized by cyclocondensation of 6aminouracil, the respective ketones and 3-formyl coumarine (2) in one pot-synthesis. Also 2-S-nucleosides analogous of pyrido[2,3-d]-pyrimidines (12-15) was synthesized b...