The nonsteroidal antiestrogen EM-800 is approximately 10-fold more potent than ICI 182 780, the most potent known steroidal antiestrogen, at inhibiting estrone-stimulated uterine weight in ovariectomized mice (half-maximal inhibitory daily s.c. doses of 0.2 and 2.0 microg, respectively). At maximal doses, however, both compounds lead to a similar maximal 90% inhibition of estrone-stimulated ute...

High grade serous ovarian carcinoma (HGSC) is a DNA instable tumor and its precursor is commonly found originating from the fimbriated end of the fallopian tube secretory epithelial (FTSE) cells. The local stresses via ovulation and related inflammation are risks for HGSC. In this study, we examined the cellular and molecular responses of FTSE cells to stress. We found that excess intracellular...

MicroRNAs, non-coding 20-22 nucleotide single-stranded RNAs, result in translational repression or degradation and gene silencing of their target genes, and significantly contribute to the regulation of gene expression. In the current study, we report that miR-182 expression was significantly upregulated in prostate cancer tissues and four cell lines, compared to benign prostatic hyperplasia ti...

Functional recovery and regeneration of corticospinal tract (CST) fibers following spinal cord injury by compression or dorsal hemisection in mice was monitored after application of the enzyme-deficient Clostridium botulinum C3-protein-derived 29-amino-acid fragment C3bot(154-182). This peptide significantly improved locomotor restoration in both injury models as assessed by the open-field Bass...

BACKGROUND AND AIM Fentanyl is widely used for relieving pain and narcotizing in cancer patients. However, there are few published reports regarding the effects of fentanyl on tumor control and treatment. Here we investigated the effects of fentanyl on tumor growth and cell invasion in the human colorectal carcinoma (HCT116) cells. METHODS Nude mice xenografts of HCT116 cells were established...

HCV entry involves a complex interplay between viral and host molecules. During post-binding interactions, the viral E2 complexes with CD81 receptor for delivery to the tight junction proteins CLDN1 and OCLN, which aid in viral internalization. Targeting HCV entry receptors represents an appealing approach to inhibit viral infectivity. This study aimed at investigating the impact of targeting C...

ENWEndNote BIBJabRef, Mendeley RISPapers, Reference Manager, RefWorks, Zotero AMA Ślęzak K, Dembiński Ł, Konefał A, et al. The impact of selected behavioural and environmental factors on the incidence upper respiratory tract infections in Polish children. Pediatria Polska - Journal Paediatrics. 2022;97(3):176-182. doi:10.5114/polp.2022.120396. APA Ślęzak, K., Dembiński, Ł., Konefał, A., Dąbrows...

MicroRNAs (miRNAs) are a class of endogenous non-coding small RNAs that post-transcriptionally control the translation and stability of target mRNAs in a sequence-dependent manner. MiRNAs are essential for key cellular processes including proliferation, differentiation, cell death and metabolism, among others. Consequently, alterations of miRNA expression contribute to developmental defects and...

Abstract Objective The aim of this study was to gather the opinion medical practitioners in India regarding modifications recently released MCI (Medical Council India) circular for faculty promotion criteria across colleges country and their suggestions further changes. Materials Methods An 11-set validated online questionnaire circulated among various country, open a period 8 days between 5 12...

Introduction: The 182 Hf– 182 W decay system (t 1/2 =9 My) is useful to date early Solar System processes, notably metal-silicate differentiation [1-10]. Hf-W systematics of refractory inclusions indicate that these objects formed with an initial 182 Hf/ 180 Hf ratio of ~1×10-4 and ε 182 W of –3.47 ± 0.20 [6]. Recent high precision studies revealed negative ε 182 W values relative to CAIs for s...