The phosphatidylinositol 3-kinase (PI3K) signaling pathway is a conserved signal transduction cascade that is fundamental for the correct development of the nervous system. The major negative regulator of PI3K signaling is the lipid phosphatase DAF-18/PTEN, which can modulate PI3K pathway activity during neurodevelopment. Here, we identify a novel role for DAF-18 in promoting neurite outgrowth ...

sive animals (21 , 24). With the help of isoelectnic focusing in polyacrylamide gel, a single binding species for TCDD could be demonstrated in liver cytosol (3). Scatchard plots for the binding of TCDD measured by using this method gave a Kd of 0.6 [email protected] of TCDD to the peak focusing at p15.2 was competed for by 3-methylcholanthrene, ,8-naphthoflavone, and TCDBF, all inducers of AHH, but n...

ÐUtilization of 17-keto-androstanes as starting materials for the synthesis of aor b-oriented steroidal 20!16-g-carbolactones has been explored following two di€erent strategies. A highly ecient, stereospeci®c protocol has been developed for the boriented cis-g-lactone. A di€erent approach, involving prior attachment of a 3-carbon side chain on C-17 of a 17-oxo-16b-acetoxyandrostane led to the...

5-Lipoxygenase (5-LO) is the key enzyme responsible for the conversion of arachidonic acid to leukotrienes, a class of lipid mediators implicated in inflammatory disorders. In this paper, we describe the design, synthesis, and preliminary activity studies of novel clicked caffeic esters and amides as radical scavengers and 5-LO inhibitors. From known 5-LO inhibitor 3 as a lead, cinnamic esters ...

In continuation of our endeavor towards the development of potent and effective antimicrobial agents, three series of halophenyl bis-hydrazones (14a-n, 16a-d, 17a and 17b) were synthesized and evaluated for their potential antibacterial, antifungal and antimycobacterial activities. These efforts led to the identification of five molecules 14c, 14g, 16b, 17a and 17b (MIC range from 0.12 to 7.81 ...

Human Bestrophin 1 (hBest1) is a calcium-activated chloride channel that regulates neuronal excitability, synaptic activity, and retinal homeostasis. Mutations in hBest1 cause the autosomal-dominant Best macular dystrophy (BMD). Because hBest1 mutations cause BMD, but a knockout does not, we wondered if hBest1 mutants exert a dominant negative effect through interaction with other calcium-activ...

The rare earth iron garnets RE3Fe5O12 (REIG hereafter) have been discovered at Grenoble (France) (Bertaut & Forrat, 1956; Bertaut et al., 1956) then independently at Murray Hill (USA) (Geller & Gilleo, 1957a, 1957b). These most studied ferrimagnetic materials have a general formula {RE3+3}[Fe3+2](Fe3+3)O12 where RE3+ can be any trivalent rare earth ion or the Yttrium Y3+. The crystal structure ...

J. Dziok Institute of Mathematics, University of Rzeszów, ul. Rejtana 16A, 35-310 Rzeszów, Poland Correspondence should be addressed to J. Dziok, [email protected] Received 2 July 2009; Revised 21 November 2009; Accepted 5 January 2010 Academic Editor: Vladimir Mityushev Copyright q 2010 J. Dziok. This is an open access article distributed under the Creative Commons Attribution License, wh...

AIM A new series of compounds (1a-16a) bearing indole-fused benzooxazepine was synthesized, characterized and evaluated for anticancer activity. MATERIALS & METHODS In this study, all the synthesized compounds were screened via in vitro anticancer testing on Hep-G2 cancer cell line. A computational study was carried out on cancer-related targets including IL-2, IL-6, COX-2 Caspase-3 and Caspa...

Wittig rearrangement of 17(20)-ethylidene-16-furfuryloxy steroids 5–8 was examined. Reaction of 17E(20)-ethylidene-16afurfuryloxy steroid 5 with t-BuLi in THF afforded (20S,22S)and (20S,22R)-22-hydroxy steroids 9, 10 and 17Z(20)-ethylidene-16a-(2furyl)hydroxymethyl steroid 11 in 61, 28, and 9% yields, respectively. Base treatment of 17E(20)-ethylidene-16b-furfuryloxy steroid 7 gave (20R,22R)-22...