OBJECTIVE The molecular mechanisms that regulate the formation of the conduction system are poorly understood. We studied the developmental expression pattern and functional aspects of the T-box transcription factor Tbx3, a novel marker for the murine central conduction system (CCS). METHODS The patterns of expression of Tbx3, and of Cx40, Cx43, and Nppa, which are markers for atrial and vent...

the aim of the present study was to develop a tissue-engineering approach through alginate gel molding to mimic cartilage tissue in a three-dimensional culture system. the perfusion biomimetic bioreactor was designed to mimic natural joint. the shear stresses exerting on the bioreactor chamber were calculated by computational fluid dynamic (cfd). several alginate/bovine chondrocyte constructs w...

the volumetric changes in the coal matrix (coal shrinkage), permeability under various gas environment conditions as well as perographical properties were studied in the laboratory. the shrinkage and permeability of coal were examined with respect to changing gas type and confining pressures. the shrinkage tests were carried out in high-pressure bombs while the permeability study was conducted ...

A well-characterized exposure chamber is necessary to generate reproducible atmospheres for inhalation toxicology studies. The aim of the present study was to characterize a head-only exposure chamber for non-human primates. Aerosols containing bovine serum albumin (BSA) were used to characterize a 16-L dynamic airflow head-only exposure chamber. A 250-ml plastic bottle with a respirator attach...

We developed a very low resistivity RPC-type detector, the anode of which was a plate made from materials with resistivity up to 5x107 Ωcm, the cathode being a metallic mesh preceded by a drift region. In such detector it was actually possible to combine the versatility and high counting-rate capability of metallic PPACs with the extreme robustness and "protectiveness" of Resistive Plate Chambe...