The aim of this systematic review is to assess the safety local anaesthetics (LA) combined with vasoconstrictors (VC) for patients controlled hypertension undergoing dental procedures. A comprehensive search strategy were used identify all relevant randomized trials (RCTs) that evaluated effect LA VC. All searches covered period from 1990 February 2021. We performed a meta-analysis using random...

A myogenic vasoconstriction may amplify the effects of circulating vasoconstrictors. In cremaster arterioles, the contribution of a myogenic component to the constriction on intravenous infusion of norepinephrine (NE) or angiotensin II (Ang II) was studied. Second, the role of endothelium-derived nitric oxide (NO) in the control of these myogenic constrictions and its site of action in the resi...

Many colorectal liver metastases are hypovascular, and their low level of perfusion is associated with limited drug uptake and poor response rates with regional chemotherapy. We have previously shown that hepatic arterial vasoconstrictors may increase drug delivery to liver tumours, but the underlying haemodynamic changes have not been defined. Using intraoperative laser Doppler flowmetry (LDF)...

Vasoconstrictors such as arginine vasopressin (AVP) and angiotensin II (Ang II) have been shown to increase protein and mRNA levels of smooth muscle a-actin (SM-a-actin) in vascular smooth muscle cells. In the same cells, platelet-derived growth factor (PDGF) decreased SM-aactin protein and mRNA. The rat SM-a-actin promoter that has recently been isolated contains two E-boxes and three CC(A/T)6...